ArticleWorld journal of gastroenterology2004
Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 92 citations in OpenAlex.
- Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population.Genetic testing and molecular biomarkers · 2022Article
- Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells.Journal of experimental & clinical cancer research : CR · 2021Article
- Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21Molecular biology of the cell · 2020Article
- Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation.Scientific reports · 2018Article
- Upregulation of GNL3 expression promotes colon cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.Oncology reports · 2017Article
- Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines.Oncology letters · 2017Article
- Gene expression profiling of NB4 cells following knockdown of nucleostemin using DNA microarrays.Molecular medicine reports · 2016Article
- Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.The Journal of biological chemistry · 2015Article
- Guanine nucleotide binding protein-like 3 is a potential prognosis indicator of gastric cancer.International journal of clinical and experimental pathology · 2015Article
- Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis.PloS one · 2015Article
- Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines.Anatomy & cell biology · 2014Article
- Nucleostemin depletion induces post-g1 arrest apoptosis in chronic myelogenous leukemia k562 cells.Advanced pharmaceutical bulletin · 2014Article
- Effect of EGF and FGF on the expansion properties of human umbilical cord mesenchymal cells.In vitro cellular & developmental biology. Animal · 2013Article
- Immunohistochemical study of doublecortin and nucleostemin in canine brain.European journal of histochemistry : EJH · 2013Article
- Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer.Journal of cancer research and clinical oncology · 2012Article
- Article
- Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.The Journal of cell biology · 2012Article
- Epstein-Barr virus-specific methylation of human genes in gastric cancer cells.Infectious agents and cancer · 2010Article
- Tumor-initiating function of nucleostemin-enriched mammary tumor cells.Cancer research · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the role of nucleostemin in the growth regulation of gastric cancer, liver cancer and other cancers.
methodsRT-PCR was used to clone the fragment of nucleostemin cDNA from HEK 293 cells. Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization.
resultsWe successfully cloned a 570 bp fragment of nucleostemin-cDNA from HEK-293 cells. All detected malignant tumor tissues, benign tumor tissues, and benign hyperplastic tissues had high levels of nucleostemin expression. Nucleostemin was also expressed in human placenta tissue at a high level. In terminally differentiated normal human adult kidney and mammary gland tissues, no nucleostemin expression could be detected.
conclusionNucleostemin can help regulate the proliferation of both cancer cells and stem cells. It might play an important role in the growth regulation of gastric cancer, liver cancer and other cancers.
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