ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2004
Clinical factors associated with fluconazole resistance and short-term survival in patients with Candida bloodstream infection.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Central venous catheter (CVC) removal for patients of all ages with candidaemia.The Cochrane database of systematic reviews · 2016Pooled it
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- Creation and Internal Validation of a Clinical Predictive Model for Fluconazole Resistance in Patients WithOpen forum infectious diseases · 2022Article
- Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience.Infection and drug resistance · 2015Article
- Antifungal pharmacokinetics and pharmacodynamics.Cold Spring Harbor perspectives in medicine · 2014Review
- Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model.Antimicrobial agents and chemotherapy · 2013Article
- Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2013Article
- Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations.Antimicrobial agents and chemotherapy · 2012Article
- The effect of cumulative length of hospital stay on the antifungal resistance of Candida strains isolated from critically ill surgical patients.Mycopathologia · 2011Article
- Risk factors for fluconazole-resistant candidemia.Antimicrobial agents and chemotherapy · 2010Article
- Evaluation by data mining techniques of fluconazole breakpoints established by the Clinical and Laboratory Standards Institute (CLSI) and comparison with those of the European Committee on Antimicrobial Susceptibility Testing (EUCAST).Antimicrobial agents and chemotherapy · 2010Article
- [Update: invasive fungal infections: Diagnosis and treatment in surgical intensive care medicine].Der Anaesthesist · 2010Review
- Association of fluconazole pharmacodynamics with mortality in patients with candidemia.Antimicrobial agents and chemotherapy · 2008Article
- Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia.Antimicrobial agents and chemotherapy · 2007Article
- Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia.Antimicrobial agents and chemotherapy · 2007Article
- Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing.Clinical microbiology reviews · 2006Review
- Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality.Antimicrobial agents and chemotherapy · 2005Article
- Time of catheter removal in candidemia and mortality.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
- Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesObservational
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a 1-year national surveillance program of Candida bloodstream infections in Japan, clinical factors predicting fluconazole resistance and survival of the patients were analyzed. Blood isolates and complete clinical histories were obtained from 326 patients. Fluconazole-resistant isolates were found in 15 (4.6%) of the cases. Univariate analysis of the demographic and clinical factors associated with fluconazole resistance revealed that age, hematologic malignancy, neutropenia, and immunosuppression were of statistical significance. A multiple logistic regression model showed that only hematologic malignancy as the underlying disease (odds ratio, 6.6; 95% confidence interval, 1.6-26.9; P=0.009) was independently associated with resistance. In 242 cases in which data regarding management and prognosis were available, the 30-day survival rate was 68.4%. In the univariate analysis of factors predicting survival, a significant association was found for Candida species, age of the patient, neutropenia, recent abdominal surgery, removal of the central venous catheter, and use of appropriate antifungal therapy. In the multivariate analysis, removal of the central venous catheter (odds ratio, 6.0; 95% confidence interval, 2.2-16.1; P<0.001) and the use of appropriate therapy (odds ratio, 2.1; 95% confidence interval, 1.1-4.1; P=0.03) were independent factors significantly associated with survival after the diagnosis of Candida bloodstream infection.
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