Evidence map›Paper›PMID 15111846›Full record

Trial reportJournal of vascular surgery2004

Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial.

Anai E S Durazzo, Fábio S Machado, Dimas T Ikeoka, Cláudia De Bernoche, Maristela C Monachini, Pedro Puech-Leão, Bruno Caramelli

Registry-linked trialOpen access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of vascular surgery, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01543555 (Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery), which is not on this map. Cited by 81 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 10 pooled it
29.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01543555 phase3completedstarted 2012, after this paper: background citation

Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery

Ran2012Enrolled648Registered outcomes10Posted comparisons0ConditionsAortic Aneurism, Myocardial Infarction, Peripheral Vascular DiseaseArmsAtorvastatin, Placebo
PMID 19726772PMID 19474688PMID 18479744PMID 17088313PMID 21464051other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 10 syntheses or guidelines pooled it, 597 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Arquivos brasileiros de cardiologia · 2017
    Guideline
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.The Cochrane database of systematic reviews · 2013 · on this map
    Pooled it
  8. Perioperative use of statins in noncardiac surgery.Vascular health and risk management · 2008
    Pooled it
  9. Pooled it
  10. Guideline
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Observational
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anai E S DurazzoHeart Institute and Vascular Surgery Department, University of São Paulo Medical School, São Paulo, Brazil. anaidurazzo@uol.com.br
Fábio S Machado
Dimas T Ikeoka
Cláudia De Bernoche
Maristela C Monachini
Pedro Puech-Leão
Bruno Caramelli
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis prospective, randomized, placebo-controlled, double-blind clinical trial was performed to analyze the effect of atorvastatin compared with placebo on the occurrence of a 6-month composite of cardiovascular events after vascular surgery. Cardiovascular complications are the most important cause of perioperative morbidity and mortality among patients undergoing vascular surgery. Statin therapy may reduce perioperative cardiac events through stabilization of coronary plaques.

methodsOne hundred patients were randomly assigned to receive 20 mg atorvastatin or placebo once a day for 45 days, irrespective of their serum cholesterol concentration. Vascular surgery was performed on average 30 days after randomization, and patients were prospectively followed up over 6 months. The cardiovascular events studied were death from cardiac cause, nonfatal myocardial infarction, unstable angina, and stroke.

resultsFifty patients received atorvastatin, and 50 received placebo. During the 6-month follow-up primary end points occurred in 17 patients, 4 in the atorvastatin group and 13 in the placebo group. The incidence of cardiac events was more than three times higher with placebo (26.0%) compared with atorvastatin (8.0%; P =.031). The risk for an event was compared between the groups with the Kaplan-Meier method, as event-free survival after vascular surgery. Patients given atorvastatin exhibited a significant decrease in the rate of cardiac events, compared with the placebo group, within 6 months after vascular surgery (P =.018).

conclusionShort-term treatment with atorvastatin significantly reduces the incidence of major adverse cardiovascular events after vascular surgery.

Indexed as

Vascular Surgical ProceduresAgedAtorvastatinCardiovascular DiseasesCholesterol, LDLDouble-Blind MethodFemaleFollow-Up StudiesHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMalePatient CompliancePostoperative ComplicationsProspective StudiesAtorvastatinCholesterol, LDLHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsPyrroles

Identifiers

PMID15111846
OpenAlexW2030475349

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.