ArticleThe Journal of general physiology2004
Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods.
Article in The Journal of general physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch.The Journal of general physiology · 2023Article
- Conformational motions and ligand-binding underlying gating and regulation in IPNature communications · 2022Article
- Modeling calcium dynamics in neurons with endoplasmic reticulum: existence, uniqueness and an implicit-explicit finite element scheme.Communications in nonlinear science & numerical simulation · 2022Article
- Ryanodine Receptor Open Times Are Determined in the Closed State.Biophysical journal · 2018Article
- Emergence of ion channel modal gating from independent subunit kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.The Journal of general physiology · 2016Article
- Cardiac alternans and ventricular fibrillation: a bad case of ryanodine receptors reneging on their duty.Circulation research · 2014Article
- Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle.Molecular pharmacology · 2014Article
- Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics.Frontiers in physiology · 2014Article
- Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP.American journal of physiology. Cell physiology · 2012Article
- A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.The Journal of general physiology · 2012Article
- MCMC estimation of Markov models for ion channels.Biophysical journal · 2011Article
- Article
- Luminal Ca(2+) content regulates intracellular Ca(2+) release in subepicardial myocytes of intact beating mouse hearts: effect of exogenous buffers.American journal of physiology. Heart and circulatory physiology · 2010Article
- Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms.Biophysical journal · 2009Article
- Inositol trisphosphate receptor and ion channel models based on single-channel data.Chaos (Woodbury, N.Y.) · 2009Article
- Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels.The Journal of general physiology · 2007Article
- Mining and state-space modeling and verification of sub-networks from large-scale biomolecular networks.BMC bioinformatics · 2007Article
- Analysis of macroscopic ionic currents mediated by GABArho1 receptors during lanthanide modulation predicts novel states controlling channel gating.British journal of pharmacology · 2005Article
- Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure.The Journal of general physiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca(2+) dynamics in heart. The processes of activation, inactivation, and regulation of these channels have been the subject of intensive research and the focus of recent debates. Typically, approaches to understand these processes involve statistical analysis of single RYRs, involving signal restoration, model estimation, and selection. These tasks are usually performed by following rather phenomenological criteria that turn models into self-fulfilling prophecies. Here, a thorough statistical treatment is applied by modeling single RYRs using aggregated hidden Markov models. Inferences are made using Bayesian statistics and stochastic search methods known as Markov chain Monte Carlo. These methods allow extension of the temporal resolution of the analysis far beyond the limits of previous approaches and provide a direct measure of the uncertainties associated with every estimation step, together with a direct assessment of why and where a particular model fails. Analyses of single RYRs at several Ca(2+) concentrations are made by considering 16 models, some of them previously reported in the literature. Results clearly show that single RYRs have Ca(2+)-dependent gating modes. Moreover, our results demonstrate that single RYRs responding to a sudden change in Ca(2+) display adaptation kinetics. Interestingly, best ranked models predict microscopic reversibility when monovalent cations are used as the main permeating species. Finally, the extended bandwidth revealed the existence of novel fast buzz-mode at low Ca(2+) concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.