ArticleBiophysical journal2004
Domain formation in phosphatidylinositol monophosphate/phosphatidylcholine mixed vesicles.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Dynamic pre-structuration of lipid nanodomain-segregating remorin proteins.Communications biology · 2024Article
- Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions.The journal of physical chemistry. B · 2024Article
- Physical Properties and Reactivity of Microdomains in Phosphatidylinositol-Containing Supported Lipid Bilayer.Membranes · 2021Article
- GαBiochemistry · 2019Article
- Nanodomain Clustering of the Plant Protein Remorin by Solid-State NMR.Frontiers in molecular biosciences · 2019Article
- Reorganization of Ternary Lipid Mixtures of Nonphosphorylated Phosphatidylinositol Interacting with Angiomotin.The journal of physical chemistry. B · 2018Article
- BaltDC: purification, characterization and infrared spectroscopy of an antiplatelet DC protein isolated fromThe journal of venomous animals and toxins including tropical diseases · 2017Article
- Conformation-Dependent Human p52Shc Phosphorylation by Human c-Src.Biochemistry · 2015Article
- Raft-like membrane domains in pathogenic microorganisms.Current topics in membranes · 2015Review
- Cholesterol stabilizes fluid phosphoinositide domains.Chemistry and physics of lipids · 2014Article
- Counterion-mediated cluster formation by polyphosphoinositides.Chemistry and physics of lipids · 2014Review
- Cellular and molecular interactions of phosphoinositides and peripheral proteins.Chemistry and physics of lipids · 2014Review
- Counterion-mediated pattern formation in membranes containing anionic lipids.Advances in colloid and interface science · 2014Review
- Divalent cation-induced cluster formation by polyphosphoinositides in model membranes.Journal of the American Chemical Society · 2012Article
- The physical chemistry of the enigmatic phospholipid diacylglycerol pyrophosphate.Frontiers in plant science · 2012Article
- Membrane microheterogeneity: Förster resonance energy transfer characterization of lateral membrane domains.European biophysics journal : EBJ · 2010Review
- Listeria monocytogenes phosphatidylinositol-specific phospholipase C: Kinetic activation and homing in on different interfaces.Biochemistry · 2009Article
- Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures.The journal of physical chemistry. B · 2009Article
- Combined electrostatics and hydrogen bonding determine intermolecular interactions between polyphosphoinositides.Journal of the American Chemical Society · 2008Article
- Solution pH alters mechanical and electrical properties of phosphatidylcholine membranes: relation between interfacial electrostatics, intramembrane potential, and bending elasticity.Biophysical journal · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Phosphoinositides have been shown to control membrane trafficking events by targeting proteins to specific cellular sites, which requires a tight regulation of phosphoinositide generation and turnover as well as a high degree of compartmentalization. To shed light on the processes that lead to the formation of phosphoinositide-enriched microdomains, phosphatidylcholine/phosphatidylinositol monophosphate (phosphatidylinositol-3-phosphate (PI-3P), -4-phosphate (PI-4P), or -5-phosphate (PI-5P)) mixed vesicles were investigated by calorimetric (DSC) Fourier transform infrared spectroscopic (FTIR), and fluorescence resonance energy transfer (FRET) measurements. The experiments furnished results consistent with a pH-dependent formation of phosphatidylinositol monophosphate-enriched microdomains. The domain formation was most pronounced between pH approximately 7 and approximately 9.5, whereas slightly acidic pH values (pH 4) resulted in the disintegration of the domains. This pH-dependent phosphatidylcholine/phosphatidylinositol monophosphate demixing was observed for the gel phase (FTIR experiments) as well as for the fluid lipid phase (FRET measurements). The observed microdomains are presumably stabilized by hydroxyl/hydroxyl as well as hydroxyl/phosphomonoester and phosphodiester interactions. While the pH dependence of the mutual phosphatidylinositol monophosphate interaction was largely the same for all investigated phosphatidylinositol monophosphates, it turned out that the relative stability of phosphatidylinositol monophosphate-enriched microdomains (pH 7-9.5) was governed by the position of the phosphomonoester group at the inositol ring (PI-4P > PI-5P > PI-3P). Demixing was also observed for phosphatidylcholine/phosphatidylinositol mixed vesicles; however, in this case the microdomain formation was only slightly affected by pH changes.
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