ArticleBiophysical journal2004
Size effects on diffusion processes within agarose gels.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Microparticles as BDMDAC (Quaternary Ammonium Compound) Carriers for Water Disinfection: A Layer-by-Layer Approach without Biocide Release.Nanomaterials (Basel, Switzerland) · 2023Article
- Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound.Gels (Basel, Switzerland) · 2023Article
- Equilibration of precipitants in a counter-diffusion apparatus for protein crystallization.Journal of applied crystallography · 2023Article
- Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels.Gels (Basel, Switzerland) · 2023Article
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- Influenza A virus diffusion through mucus gel networks.Communications biology · 2022Article
- Small Oligonucleotides Detection in Three-Dimensional Polymer Network of DNA-PEG Hydrogels.Gels (Basel, Switzerland) · 2021Article
- Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin-microtubule networks.Soft matter · 2021Article
- Speciation of Inorganic Compounds in Aquatic Systems Using Diffusive Gradients in Thin-Films: A Review.Frontiers in chemistry · 2021Review
- Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models.Gene expression · 2020Article
- Pore-size dependence and slow relaxation of hydrogel friction on smooth surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Formation of phage lysis patterns and implications on co-propagation of phages and motile host bacteria.PLoS computational biology · 2020Article
- Assaying How Phagocytic Success Depends on the Elasticity of a Large Target Structure.Biophysical journal · 2019Article
- Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound.Scientific reports · 2019Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
To investigate diffusion processes in agarose gel, nanoparticles with sizes in the range between 1 and 140 nm have been tested by means of fluorescence correlation spectroscopy. Understanding the diffusion properties in agarose gels is interesting, because such gels are good models for microbial biofilms and cells cytoplasm. The fluorescence correlation spectroscopy technique is very useful for such investigations due to its high sensitivity and selectivity, its excellent spatial resolution compared to the pore size of the gel, and its ability to probe a wide range of sizes of diffusing nanoparticles. The largest hydrodynamic radius (R(c)) of trapped particles that displayed local mobility was estimated to be 70 nm for a 1.5% agarose gel. The results showed that diffusion of particles in agarose gel is anomalous, with a diverging fractal dimension of diffusion when the large particles become entrapped in the pores of the gel. The latter situation occurs when the reduced size (R(A)/R(c)) of the diffusing particle, A, is >0.4. Variations of the fractal exponent of diffusion (d(w)) with the reduced particle size were in agreement with three-dimensional Monte Carlo simulations in porous media. Nonetheless, a systematic offset of d(w) was observed in real systems and was attributed to weak nonelastic interactions between the diffusing particles and polymer fibers, which was not considered in the Monte Carlo simulations.
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