ArticleBiophysical journal2004
Release currents of IP(3) receptor channel clusters and concentration profiles.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Luminal transport through intact endoplasmic reticulum limits the magnitude of localized CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modeling IPBiophysical journal · 2023Article
- T cell CaFrontiers in immunology · 2023Review
- Termination of CaCell calcium · 2021Article
- Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells.Biophysical journal · 2021Article
- Three-Dimensional Model of Sub-Plasmalemmal CaFrontiers in immunology · 2021Article
- Bicarbonate permeation through anion channels: its role in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Fundamentals of Cellular Calcium Signaling: A Primer.Cold Spring Harbor perspectives in biology · 2020Review
- Extension of Rapid Buffering Approximation to CaBiophysical journal · 2018Article
- Padé Approximation of a Stationary Single-Channel CaBiophysical journal · 2016Article
- Calcium waves in a grid of clustered channels with synchronous IPThe European physical journal. E, Soft matter · 2016Article
- A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles.Frontiers in physiology · 2015Article
- Frequency and relative prevalence of calcium blips and puffs in a model of small IP₃R clusters.Biophysical journal · 2014Article
- Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches.Frontiers in pharmacology · 2014Review
- Do calcium buffers always slow down the propagation of calcium waves?Journal of mathematical biology · 2013Article
- A stochastic model of calcium puffs based on single-channel data.Biophysical journal · 2013Article
- Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Multi-scale data-driven modeling and observation of calcium puffs.Cell calcium · 2012Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We simulate currents and concentration profiles generated by Ca(2+) release from the endoplasmic reticulum (ER) to the cytosol through IP(3) receptor channel clusters. Clusters are described as conducting pores in the lumenal membrane with a diameter from 6 nm to 36 nm. The endoplasmic reticulum is modeled as a disc with a radius of 1-12 microm and an inner height of 28 nm. We adapt the dependence of the currents on the trans Ca(2+) concentration (intralumenal) measured in lipid bilayer experiments to the cellular geometry. Simulated currents are compared with signal mass measurements in Xenopus oocytes. We find that release currents depend linearly on the concentration of free Ca(2+) in the lumen. The release current is approximately proportional to the square root of the number of open channels in a cluster. Cytosolic concentrations at the location of the cluster range from 25 microM to 170 microM. Concentration increase due to puffs in a distance of a few micrometers from the puff site is found to be in the nanomolar range. Release currents decay biexponentially with timescales of <1 s and a few seconds. Concentration profiles decay with timescales of 0.125-0.250 s upon termination of release.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.