ArticleBiophysical journal2004
Pulling-speed-dependent force-extension profiles for semiflexible chains.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Interplay between Viscoelasticity and Force Rate Affects Sequential Unfolding in Polyproteins Pulled at Constant Velocity.Macromolecules · 2020Article
- Entropic bonding of the type 1 pilus from experiment and simulation.Royal Society open science · 2020Article
- Article
- Quantifying the free energy landscape between polymers and minerals.Scientific reports · 2017Article
- Article
- Stress Analysis at the Molecular Level: A Forced Cucurbituril-Guest Dissociation Pathway.Journal of chemical theory and computation · 2010Article
- Compressing a rigid filament: buckling and cyclization.The European physical journal. E, Soft matter · 2007Article
- Stretching dynamics of semiflexible polymers.The European physical journal. E, Soft matter · 2007Article
- Multiscale modeling of nucleosome dynamics.Biophysical journal · 2007Article
- Forced-unfolding and force-quench refolding of RNA hairpins.Biophysical journal · 2006Article
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2 authors.
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Abstract
We present theory and simulations to describe nonequilibrium stretching of semiflexible chains that serve as models of DNA molecules. Using a self-consistent dynamical variational approach, we calculate the force-extension curves for worm-like chains as a function of the pulling speed, v(0). Due to nonequilibrium effects the stretching force, which increases with v(0), shows nonmonotonic variations as the persistence length increases. To complement the theoretical calculations we also present Langevin simulation results for extensible worm-like chain models for the dynamics of stretching. The theoretical force-extension predictions compare well with the simulation results. The simulations show that, at high enough pulling speeds, the propagation of tension along the chain conformations transverse to the applied force occurs by the Brochard-Wyart's stem-flower mechanism. The predicted nonequilibrium effects can only be observed in double-stranded DNA at large ( approximately 100 microm/s) pulling speeds.
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