ArticleDevelopmental biology2004
Drawing lines in the sand: even skipped et al. and parasegment boundaries.
Article in Developmental biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
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- Recent approaches lead to a deeper understanding of diverse segmentation mechanisms in insects, with a focus on the pair-rule genes.Current opinion in insect science · 2025Review
- The ftz upstream element drives late ftz stripes but is not required for regulation of Ftz target genes.Developmental biology · 2024Article
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- Quantitative Comparison of the Anterior-Posterior Patterning System in the Embryos of FiveG3 (Bethesda, Md.) · 2019Article
- Dynamic expression of Drosophila segmental cell surface-encoding genes and their pair-rule regulators.Developmental biology · 2019Article
- Conservation and variation in pair-rule gene expression and function in the intermediate-germ beetleDevelopment (Cambridge, England) · 2017Article
- Dynamic patterning by the Drosophila pair-rule network reconciles long-germ and short-germ segmentation.PLoS biology · 2017Article
- Regulation and function of odd-paired in Tribolium segmentation.Development genes and evolution · 2017Article
- Ancient role ofHereditas · 2017Article
- Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton.PLoS genetics · 2016Article
- Odd-paired controls frequency doubling ineLife · 2016Article
- Article
- Co-regulation of invected and engrailed by a complex array of regulatory sequences in Drosophila.Developmental biology · 2014Article
- Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired.Developmental biology · 2012Article
- Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers.Developmental biology · 2012Article
- How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation.Development (Cambridge, England) · 2011Article
- Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates.Development (Cambridge, England) · 2011Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The pair-rule segmentation gene even skipped (eve) is required to activate engrailed stripes and to organize odd-numbered parasegments (PSs). The protein product Eve has been shown to be an active repressor of transcription, and recent models for Eve function suggest that activation of engrailed is indirect, but these models have not been fully tested. Here we identify the forkhead domain transcription factor Sloppy-paired as the key intermediate in the initial activation of engrailed by Eve in odd-numbered parasegments. We also analyze the roles of the transcription factors Runt and Odd-skipped in this process. Detailed analysis of engrailed and pair-rule gene expression in various mutant combinations shows how eve activates engrailed by repressing these engrailed repressors, and further indicates that mutual repression among pair-rule genes plays an important role in establishing parasegment boundaries. We present a new model of pair-rule gene function that explains the response of these boundaries to the relative levels of Eve and Fushi Tarazu.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.