ArticleHuman genetics2004
Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 120 citations in OpenAlex.
- Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384.Journal of acquired immune deficiency syndromes (1999) · 2011Trial
- Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson's disease.Biological research · 2025Review
- Probing the diagnostic values of plasma cf-nDNA and cf-mtDNA for Parkinson's disease and multiple system atrophy.Frontiers in neuroscience · 2024Article
- Neurological manifestations in adult patients with the m.3243A>G variant in mitochondrial DNA.BMJ neurology open · 2024Article
- Article
- Evidence for the Role of Mitochondrial DNA Release in the Inflammatory Response in Neurological Disorders.International journal of molecular sciences · 2021Review
- Review
- Testosterone enhances mitochondrial complex V function in the substantia nigra of aged male rats.Aging · 2020Article
- Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2020Review
- The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.Neurochemistry international · 2019Review
- Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure.International journal of molecular sciences · 2019Review
- Review
- Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson's Disease?Genes · 2017Review
- Genetic risk factors in Finnish patients with Parkinson's disease.Parkinsonism & related disorders · 2017Article
- Relationship between mitochondrial DNA A10398G polymorphism and Parkinson's disease: a meta-analysis.Oncotarget · 2017Article
- Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration.Frontiers in immunology · 2017Review
- Female genetic distribution bias in mitochondrial genome observed in Parkinson's Disease patients in northern China.Scientific reports · 2015Article
- Mitochondrial DNA sequence variation is largely conserved at birth with rare de novo mutations in neonates.American journal of obstetrics and gynecology · 2015Observational
- Cypermethrin-induced nigrostriatal dopaminergic neurodegeneration alters the mitochondrial function: a proteomics study.Molecular neurobiology · 2015Article
- Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment.Environmental health : a global access science source · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of complex I of the mitochondrial respiratory chain has been found to be decreased in patients with Parkinson's disease (PD), but no mutations have been identified in genes encoding complex I subunits. Recent studies have suggested that polymorphisms in mitochondrial DNA (mtDNA)-encoded complex I genes (MTND) modify susceptibility to PD. We hypothesize that the risk of PD is conveyed by the total number of nonsynonymous substitutions in the MTND genes in various mtDNA lineages rather than by single mutations. To test this possibility, we determined the number of nonsynonymous substitutions of the seven MTND genes from 183 Finns. The differences in the total number of nonsynonymous substitutions and the nonsynonymous to synonymous substitution rate ratio ( K(a)/ K(s)) of MTND genes between the European mtDNA haplogroup clusters (HV, JT, KU, IWX) were analysed by using a statistical approach. Patients with PD ( n=238) underwent clinical examination together with mtDNA haplogroup analysis and the clinical features between patient groups defined by the number of nonsynonymous substitutions were compared. Our analysis revealed that the haplogroup clusters HV and KU had a lower average number of amino acid replacements and a lower K(a)/ K(s) ratio in the MTND genes than clusters JT and IWX. Supercluster JTIWX with the highest number of amino acid replacements was more frequent among PD patients and even more frequent among patients with PD who developed dementia. Our results suggest that a relative excess of nonsynonymous mutations in MTND genes in supercluster JTWIX is associated with an increased risk of PD and the disease progression to dementia.
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