ArticlePflugers Archiv : European journal of physiology2004
Persistent and selective effects of inflammation on smooth muscle cell contractility in rat colitis.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Macrophage Immune-Competent Colon Assembloids for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility.Gastro hep advances · 2026Article
- Characterization of ulcerative colitis-associated constipation syndrome (proximal constipation).JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Gender-differences of in vitro colonic motility after chemo- and radiotherapy in humans.BMC pharmacology & toxicology · 2018Article
- Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ.Journal of cellular and molecular medicine · 2014Article
- Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.PloS one · 2014Article
- Alteration of neuromuscular transmissions in the hamster colon following the resolution of TNBS-induced colitis.The journal of physiological sciences : JPS · 2013Article
- The pro-inflammatory cytokines IL-1β and TNFα are neurotrophic for enteric neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Cell culture retains contractile phenotype but epigenetically modulates cell-signaling proteins of excitation-contraction coupling in colon smooth muscle cells.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- STW 5 is effective in dextran sulfate sodium-induced colitis in rats.International journal of colorectal disease · 2012Article
- Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders.World journal of gastrointestinal pathophysiology · 2011Article
- Control of enteric neuromuscular functions by purinergic A(3) receptors in normal rat distal colon and experimental bowel inflammation.British journal of pharmacology · 2010Article
- Neuroinflammation in inflammatory bowel disease.Journal of neuroinflammation · 2010Review
- The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.British journal of pharmacology · 2010Article
- TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Impaired acetylcholine-induced smooth muscle contraction in colitis involves altered calcium mobilization and AKT phosphorylation.Pflugers Archiv : European journal of physiology · 2008Article
- Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.Digestive diseases and sciences · 2008Article
- Mechanism of reduced colonic contractility in experimental colitis: role of sarcoplasmic reticulum pump isoform-2.Molecular and cellular biochemistry · 2007Article
- Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.Molecular pain · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal inflammation affects smooth muscle contractility contributing to altered motility, but changes to the individual smooth muscle cells are not well described. We used video microscopy to study the contractility of circular smooth muscle cells (CSMC) isolated from the rat mid-descending colon throughout the course of TNBS-induced colitis, measuring their shortening response to carbachol (CCh), 5-HT, histamine or high K(+). In control CSMC, CCh caused a maximal shortening response of 28 (2%), similar to that for 5-HT of 27 (1%), but by day 4 of colitis, these responses were decreased by 35% and 37%, respectively. By day 36, all aspects of cholinergic contraction returned to control levels, while 5-HT-induced contraction remained significantly attenuated. In contrast, the contractile responses to histamine remained similar at all time points. K(+)-induced contraction was impaired only on day 4, and the maximal response remained substantially greater than CCh or 5-HT. Colitis caused a 121% increase in CSMC length by day 2 that persisted through day 36, independent evidence for phenotypic change. We conclude that impaired CSMC contractility at both the receptor and non-receptor levels contribute to altered smooth muscle function during colitis. Persistent changes in contractile response remained detectable after resolution of inflammation, and similar events may occur in post-enteritis syndromes seen in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.