ArticleMedical microbiology and immunology2005
Increased susceptibility of male BALB/c mice to coxsackievirus B3-induced myocarditis: role for CD1d.
Article in Medical microbiology and immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Epidemiology and prognosis of pediatric acute myocarditis: a 5-year retrospective study in Shiraz, South of Iran running title: pediatric acute myocarditis in Iran.BMC cardiovascular disorders · 2025Article
- The Role and Implications of COVID-19 in Incident and Prevalent Heart Failure.Current heart failure reports · 2024Review
- Sex and Age Characteristics in Acute or Chronic Myocarditis A Descriptive, Multicenter Cohort Study.JACC. Advances · 2024Article
- Article
- Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination.Frontiers in immunology · 2022Article
- Sex-Specific Differences of the Inflammatory State in Experimental Autoimmune Myocarditis.Frontiers in immunology · 2021Article
- Sex differences in inflammation, redox biology, mitochondria and autoimmunity.Redox biology · 2020Review
- The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4Virulence · 2018Article
- The anti-obesity drug orlistat reveals anti-viral activity.Medical microbiology and immunology · 2015Article
- Autoimmune myocarditis, valvulitis, and cardiomyopathy.Current protocols in immunology · 2013Article
- Sex and gender differences in myocarditis and dilated cardiomyopathy.Current problems in cardiology · 2013Review
- Update on coxsackievirus B3 myocarditis.Current opinion in rheumatology · 2012Review
- Sex differences in murine susceptibility to systemic viral infections.Journal of autoimmunity · 2012Article
- Gender differences in autoimmunity associated with exposure to environmental factors.Journal of autoimmunity · 2012Review
- Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis.Expert review of clinical immunology · 2012Review
- Histamine H(1) receptor signaling regulates effector T cell responses and susceptibility to coxsackievirus B3-induced myocarditis.Cellular immunology · 2012Article
- Prostaglandin I₂promotes the development of IL-17-producing γδ T cells that associate with the epithelium during allergic lung inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulation and function of IL-17A- and IL-22-producing γδ T cells.Cellular and molecular life sciences : CMLS · 2011Review
- Cross-talk between cd1d-restricted nkt cells and γδ cells in t regulatory cell response.Virology journal · 2011Review
- Presumptive myocarditis with ST-Elevation myocardial infarction presentation in young males as a new syndrome. Clinical significance and long term follow up.Cardiovascular ultrasound · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
BALB/c male mice infected with the H3 variant of coxsackievirus B3 (CVB3) develop fulminant myocarditis. Age-matched female mice show little myocarditis due to decreased virus receptor expression on cardiac cells. TNFalpha and IL-1beta levels were increased in males by 3 days after infection. IFNgamma levels increased more slowly throughout the 7-day observation period. CD4+, CD8+, macrophage (Mac3+) and gammadelta+ cells all accumulated in male hearts, with gammadelta+ cells showing early (day 3) infiltration. Females also accumulated CD4+ cells, but few of the other cell types. CD4+ cells in male hearts predominately produced IFNgamma, indicating a Th1 cell phenotype, whereas CD4+ cells in females produced IL-4, but little IFNgamma, indicating a Th2 phenotype. CD1d, a major histocompatibility complex I-like molecule often implicated in innate immunity, was increased in CVB3-infected male but not female cardiocytes both in vivo and in vitro. These results demonstrate that CVB3 infections produce gender-specific differences in both innate and adaptive immunity, which may explain the difference in disease susceptibility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.