ArticleOncogene2004
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Barrett's Epithelium to Esophageal Adenocarcinoma: Is There a "Point of No Return"?Frontiers in genetics · 2021Article
- Hedgehog-mesenchyme gene signature identifies bi-modal prognosis in luminal and basal breast cancer sub-types.Molecular bioSystems · 2017Article
- The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes.Journal of neurovirology · 2017Article
- Changes in gene expression of neo-squamous mucosa after endoscopic treatment for dysplastic Barrett's esophagus and intramucosal adenocarcinoma.United European gastroenterology journal · 2017Article
- Discrimination of normal and esophageal cancer plasma proteomes by MALDI-TOF mass spectrometry.Digestive diseases and sciences · 2015Article
- Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo.Gastroenterology research and practice · 2013Article
- Article
- Predictors of progression in Barrett's esophagus: current knowledge and future directions.The American journal of gastroenterology · 2010Review
- Renal gene and protein expression signatures for prediction of kidney disease progression.The American journal of pathology · 2009Article
- Progressive silencing of p14ARF in oesophageal adenocarcinoma.Journal of cellular and molecular medicine · 2009Article
- Gene expression in Barrett's esophagus: laser capture versus whole tissue.Scandinavian journal of gastroenterology · 2009Article
- Differential gene expression in normal esophagus and Barrett's esophagus.Journal of gastroenterology · 2009Article
- A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett's associated adenocarcinoma.Oncogene · 2008Article
- In vivo cancer biomarkers of esophageal neoplasia.Cancer biomarkers : section A of Disease markers · 2008Review
- Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma.Bioinformatics and biology insights · 2007Article
- Surgical management of esophagogastric junction tumors.World journal of gastroenterology · 2006Review
- Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis.Oncogene · 2006Article
- Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus.Oncogene · 2006Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
In order to identify genes or combination of genes that have the power to discriminate between premalignant Barrett's esophagus and Barrett's associated adenocarcinoma, we analysed a panel of 23 genes using quantitative real-time RT-PCR (qRT-PCR, Taqman and bioinformatic tools. The genes chosen were either known to be associated with Barrett's carcinogenesis or were filtered from a previous cDNA microarray study on Barrett's adenocarcinoma. A total of 98 tissues, obtained from 19 patients with Barrett's esophagus (BE group) and 20 patients with Barrett's associated esophageal adenocarcinoma (EA group), were studied. Triplicate analysis for the full 23 gene of interest panel, and analysis of an internal control gene, was performed for all samples, for a total of more than 9016 single PCR reactions. We found distinct classes of gene expression patterns in the different types of tissues. The most informative genes clustered in six different classes and had significantly different expression levels in Barrett's esophagus tissues compared to adenocarcinoma tissues. Linear discriminant analysis (LDA) distinguished four genetically different groups. The normal squamous esophagus tissues from patients with BE or EA were not distinguishable from one another, but Barrett's esophagus tissues could be distinguished from adenocarcinoma tissues. Using the most informative genes, obtained from a logistic regression analysis, we were able to completely distinguish between benign Barrett's and Barrett's adenocarcinomas. This study provides the first non-array parallel mRNA quantitation analysis of a panel of genes in the Barrett's esophagus model of multistage carcinogenesis. Our results suggest that mRNA expression quantitation of a panel of genes can discriminate between premalignant and malignant Barrett's disease. Logistic regression and LDAs can be used to further identify, from the complete panel, gene subsets with the power to make these diagnostic distinctions. Expression analysis of a limited number of highly selected genes may have clinical usefulness for the treatment of patients with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.