ArticleThe Journal of physiology2004
Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Regulation of GABAMembranes · 2021Review
- The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021Article
- A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons.Cerebral cortex communications · 2020Article
- KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition.Nature communications · 2019Article
- Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex.Frontiers in cellular neuroscience · 2018Article
- Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis.Journal of biomedical science · 2017Review
- Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synchronization of action potentials during low-magnesium-induced bursting.Journal of neurophysiology · 2015Article
- How can we identify ictal and interictal abnormal activity?Advances in experimental medicine and biology · 2014Review
- Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events.Journal of neurophysiology · 2013Article
- Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy.The Journal of physiology · 2013Article
- Pyramidal cells accumulate chloride at seizure onset.Neurobiology of disease · 2012Article
- Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons.PloS one · 2012Article
- GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity.Progress in neurobiology · 2011Review
- Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics.Journal of computational neuroscience · 2009Article
- Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation.The Journal of physiology · 2008Article
- Balanced excitatory and inhibitory inputs to cortical neurons decouple firing irregularity from rate modulations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Mechanisms of seizure propagation in a cortical model.Journal of computational neuroscience · 2007Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently reported that excitatory GABAergic and glutamatergic mechanisms may be involved in the generation of seizure-like (ictal) rhythmic synchronization (afterdischarge), induced by a strong synaptic stimulation of the CA1 pyramidal cells in the mature rat hippocampus in vitro. To clarify the network mechanism of this neuronal synchronization, dual whole-cell patch-clamp recordings of the afterdischarge responses were performed simultaneously from a variety of interneurones and their neighbouring pyramidal cells in hippocampal CA1-isolated slice preparations. According to morphological and electrophysiological criteria, the recorded interneurones were then classified into distinct subtypes. The non-fast-spiking interneurones located in the strata lacunosum-moleculare and radiatum hardly discharged during the afterdischarge, whereas most of the fast-spiking and non-fast-spiking interneurones in the strata oriens and pyramidale, including the basket, chandelier and bistratified cells, exhibited prominent firings that were precisely synchronous with oscillatory responses in the pyramidal cells. Field potential recordings showed that excitatory synaptic transmissions might take place primarily in the strata oriens and pyramidale during the afterdischarge. Restricted lesions in the strata oriens and pyramidale, but not in the other layers, resulted in the complete desynchronization of afterdischarge activity, and also, local application of glutamate receptor antagonists to these layers blocked the expression of afterdischarge. The present findings indicate that the neuronal synchronization of epileptic afterdischarge may be accomplished in a 'positive feedback circuit' formed by the excitatory GABAergic interneurones and the glutamatergic pyramidal cells within the strata oriens and/or pyramidale of the hippocampal CA1 region.
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