Trial reportEmergency medicine journal : EMJ2004
The Lancaster experience of 2.0 to 2.5 mg/kg intramuscular ketamine for paediatric sedation: 501 cases and analysis.
Trial report in Emergency medicine journal : EMJ, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Efficacy of ketamine in improving pain after tonsillectomy in children: meta-analysis.PloS one · 2014Pooled it
- The effect of ketamine on affective modulation of the startle reflex and its resting-state brain correlates.Scientific reports · 2023Trial
- The incidence of unpleasant dreams after sub-anaesthetic ketamine.Psychopharmacology · 2009Trial
- Is atropine needed with ketamine sedation? A prospective, randomised, double blind study.Emergency medicine journal : EMJ · 2006Trial
- Comparison of the Effect of Intravenous Fentanyl with Low-Dose Ketamine on Pain Relief in Patients Taking Methadone and Suffering from Limb Fractures.Advanced biomedical research · 2023Article
- Effects of fentanyl overdose-induced muscle rigidity and dexmedetomidine on respiratory mechanics and pulmonary gas exchange in sedated rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Incidence and predictors of respiratory adverse events in children undergoing procedural sedation with intramuscular ketamine in a paediatric emergency department.Singapore medical journal · 2022Article
- Clinical Efficacy of Dexmedetomidine versus Ketamine in Shoulder Dislocation Reduction: A Randomized Clinical Trial Study.Medical journal of the Islamic Republic of Iran · 2021Article
- Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques.PloS one · 2020Article
- Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children.Journal of clinical pharmacology · 2018Article
- Ketamine versus Ketamine / magnesium Sulfate for Procedural Sedation and Analgesia in the Emergency Department: A Randomized Clinical Trial.Advanced biomedical research · 2018Article
- Predictors of emesis in children undergoing procedural sedation with intramuscular ketamine in a paediatric emergency department.Singapore medical journal · 2017Observational
- A Randomized Clinical Trial of Intravenous and Intramuscular Ketamine for Pediatric Procedural Sedation and Analgesia.Emergency (Tehran, Iran) · 2015Article
- Procedural sedation for pediatric patients in the emergency department at King Khalid University Hospital, Riyadh, K.S.A.Journal of emergencies, trauma, and shock · 2014Article
- Pediatric fractures: temporal trends and cost implications of treatment under general anesthesia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2012Article
- Ketamine for paediatric sedation/analgesia in the emergency department.Emergency medicine journal : EMJ · 2004Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo report the experience of using intramuscular ketamine 2.0 or 2.5 mg/kg for minor painful procedures in children in a medium sized district general hospital accident and emergency department. To demonstrate the safety and acceptability of ketamine and determine if the incidence of adverse effects is related to dose or other variables.
methodsProspective data collection and analysis using Statsdirect and SPSS software.
results501 consecutive cases were collected from August 1996 to April 2002. A total of 310 children received 2.0 mg/kg and 191 received 2.5 mg/kg. Twenty six received a second dose. In seven cases oxygen saturation fell below 93%, three of these fell below 90%. There was one case of laryngospasm. Eight cases received airway suctioning, five of these were mouth or lip wounds. Seventeen per cent vomited in recovery or at home for which one child required admission. Muscle hypertonicity was observed in 6.8%, disturbed sleep or nightmares in 2%. The median time to discharge was 85 minutes. Ninety seven per cent of parents' experiences were "the same as" or "better than" expected. No children suffered any lasting or troublesome complications.
conclusions2.0 - 2.5 mg/kg intramuscular ketamine sedation is a safe and acceptable technique when used within a defined protocol. Lower dose ketamine (2 mg/kg) warrants further study in view of potentially less airway complications and quicker discharge times than previously reported.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.