ArticleEMBO reports2004
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
Article in EMBO reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatial and temporal control of expression with light-gated LOV-LexA.G3 (Bethesda, Md.) · 2022Article
- The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.PLoS genetics · 2019Article
- A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in AdultG3 (Bethesda, Md.) · 2018Article
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- Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.Developmental cell · 2012Article
- Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.Neurobiology of disease · 2012Article
- In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.Molecular and cellular biology · 2010Article
- Characterization of an atypical gamma-secretase complex from hematopoietic origin.Biochemistry · 2010Article
- Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors.Development (Cambridge, England) · 2010Article
- X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.Neurobiology of disease · 2009Article
- Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.PloS one · 2008Article
- Rhomboid cleaves Star to regulate the levels of secreted Spitz.The EMBO journal · 2007Article
- The amyloid-beta precursor protein: integrating structure with biological function.The EMBO journal · 2005Review
- Homo- and heterodimerization of APP family members promotes intercellular adhesion.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report here the development of an in vivo reporter system that allowed us to analyse the processing of human amyloid precursor protein (APP) and the Notch receptor tissue specifically during Drosophila development in the living organism. Using this system, we demonstrate differences between APP and Notch processing and show that PS-mediated cleavage of APP can be regulated in different cell types independent of the size of the extracellular domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.