ArticleProceedings of the National Academy of Sciences of the United States of America2004
Developmental stage differences in chromatin subdomains of the beta-globin locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Comprehensive regulation of γ-globin expression by epigenetic modifications and protein post-translational modifications.Clinical epigenetics · 2025Review
- The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.Cell reports · 2018Article
- Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus.Bioscience reports · 2015Article
- Epigenetic modifications and chromosome conformations of the beta globin locus throughout development.Stem cell reviews and reports · 2013Article
- Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.Blood · 2011Article
- HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells.Molecular cancer research : MCR · 2011Article
- Article
- Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.American journal of physiology. Cell physiology · 2009Article
- A positive role for NLI/Ldb1 in long-range beta-globin locus control region function.Molecular cell · 2007Article
- Article
- Article
- Linear distance from the locus control region determines epsilon-globin transcriptional activity.Molecular and cellular biology · 2007Article
- The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.Molecular and cellular biology · 2007Article
- Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.PloS one · 2007Article
- Beta-globin intergenic transcription and histone acetylation dependent on an enhancer.Molecular and cellular biology · 2007Article
- Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.Molecular and cellular biology · 2007Article
- Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences.Molecular and cellular biology · 2007Article
- A facilitated tracking and transcription mechanism of long-range enhancer function.Nucleic acids research · 2007Article
- Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites.Nucleic acids research · 2007Article
- Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian beta-globin loci each contain a family of developmentally expressed genes, and a far upstream regulatory element, the locus control region (LCR). In adult murine erythroid cells, the LCR and the transcribed beta-globin genes exist within domains of histone acetylation and RNA polymerase II (pol II) is associated with them. In contrast, the silent embryonic genes lie between these domains within hypoacetylated chromatin, and pol II is not found there. We used chromatin immunoprecipitation and real-time PCR to analyze histone modification and pol II recruitment to the globin locus in human erythroid K562 cells that express the embryonic epsilon-globin gene but not the adult beta-globin gene. H3 and H4 acetylation and H3 K4 methylation were continuous over a 17-kb region including the LCR and the active epsilon-globin gene. The level of modification varied directly with the transcription of the epsilon-globin gene. In contrast, this region in nonerythroid HeLa cells lacked these modifications and displayed instead widespread H3 K9 methylation. pol II was also detected continuously from the LCR to the epsilon-globin gene. These studies reveal several aspects of chromatin structure and pol II distribution that distinguish the globin locus at embryonic and adult stages and suggest that both enhancer looping and tracking mechanisms may contribute to LCR-promoter communication at different developmental stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.