ArticleAntimicrobial agents and chemotherapy2004
Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotype.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 106 citations in OpenAlex.
- Chemoenzymatic Synthesis of Well-Defined α(2,8)- and α(2,9)-Linked Oligosialosides.Angewandte Chemie (International ed. in English) · 2026Article
- Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy.Advanced therapeutics · 2024Article
- Phage-encoded depolymerases as a strategy for combating multidrug-resistantFrontiers in cellular and infection microbiology · 2024Review
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- Phage Targeting Neonatal MeningitisInternational journal of molecular sciences · 2023Article
- Evolutionary and functional history of the Escherichia coli K1 capsule.Nature communications · 2023Article
- Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application.Antibiotics (Basel, Switzerland) · 2021Review
- Article
- Characterisation of Bacteriophage-Encoded Depolymerases Selective for KeyFrontiers in cellular and infection microbiology · 2021Article
- Differential Bacteriophage Efficacy in ControllingFrontiers in microbiology · 2021Article
- Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae.Infection and immunity · 2020Article
- A Novel Tail-Associated O91-Specific Polysaccharide Depolymerase from a Podophage Reveals Lytic Efficacy of Shiga Toxin-Producing Escherichia coli.Applied and environmental microbiology · 2020Article
- Phloretin Protects Macrophages fromJournal of microbiology and biotechnology · 2020Article
- Genomic and Phenotypic Analyses ofFrontiers in microbiology · 2020Article
- Article
- Antiseptic Effect of Ps-K18: Mechanism of Its Antibacterial and Anti-Inflammatory Activities.International journal of molecular sciences · 2019Article
- Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal PathogenInfection and immunity · 2019Article
- A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-ResistantFrontiers in microbiology · 2019Article
- Diversity and Function of Phage Encoded Depolymerases.Frontiers in microbiology · 2019Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Escherichia coli is a common cause of meningitis and sepsis in the newborn infant, and the large majority of isolates from these infections produce a polysialic acid (PSA) capsular polysaccharide, the K1 antigen, that protects the bacterial cell from immune attack. We determined whether a capsule-depolymerizing enzyme, by removing this protective barrier, could alter the outcome of systemic infection in an animal model. Bacteriophage-derived endosialidase E (endoE) selectively degrades the PSA capsule on the surface of E. coli K1 strains. Intraperitoneal administration of small quantities of recombinant endoE (20 micro g) to 3-day-old rats, colonized with a virulent strain of K1, prevented bacteremia and death from systemic infection. The enzyme had no effect on the viability of E. coli strains but sensitized strains expressing PSA to killing by the complement system. This study demonstrates the potential therapeutic efficacy of agents that cure infections by modification of the bacterial phenotype rather than by killing or inhibition of growth of the pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.