ArticleTissue antigens2004
SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation.
Article in Tissue antigens, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- HLA repertoire of 115 UAE nationals infected with SARS-CoV-2.Human immunology · 2022Article
- The pockets guide to HLA class I molecules.Biochemical Society transactions · 2021Review
- Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics.Cell reports · 2021Article
- An immunogenetic view of COVID-19.Genetics and molecular biology · 2021Article
- Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses.F1000Research · 2021Article
- AI Aided Design of Epitope-Based Vaccine for the Induction of Cellular Immune Responses Against SARS-CoV-2.Frontiers in genetics · 2021Article
- Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools.Scientific reports · 2020Article
- Role of in silico structural modeling in predicting immunogenic neoepitopes for cancer vaccine development.JCI insight · 2020Article
- Article
- TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates.Current protocols in immunology · 2016Article
- Classification of human leukocyte antigen (HLA) supertypes.Methods in molecular biology (Clifton, N.J.) · 2014Article
- HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- A combination of epitope prediction and molecular docking allows for good identification of MHC class I restricted T-cell epitopes.Computational biology and chemistry · 2013Article
- Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture.Current protocols in immunology · 2013Article
- Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?Expert review of vaccines · 2012Article
- Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities.Immunogenetics · 2011Article
- Article
- Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development.Virology journal · 2010Review
- Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
An effective Severe Acute Respiratory Syndrome (SARS) vaccine is likely to include components that can induce specific cytotoxic T-lymphocyte (CTL) responses. The specificities of such responses are governed by human leukocyte antigen (HLA)-restricted presentation of SARS-derived peptide epitopes. Exact knowledge of how the immune system handles protein antigens would allow for the identification of such linear sequences directly from genomic/proteomic sequence information (Lauemoller et al., Rev Immunogenet 2001: 2: 477-91). The latter was recently established when a causative coronavirus (SARS-CoV) was isolated and full-length sequenced (Marra et al., Science 2003: 300: 1399-404). Here, we have combined advanced bioinformatics and high-throughput immunology to perform an HLA supertype-, genome-wide scan for SARS-specific CTL epitopes. The scan includes all nine human HLA supertypes in total covering >99% of all individuals of all major human populations (Sette & Sidney, Immunogenetics 1999: 50: 201-12). For each HLA supertype, we have selected the 15 top candidates for test in biochemical binding assays. At this time (approximately 6 months after the genome was established), we have tested the majority of the HLA supertypes and identified almost 100 potential vaccine candidates. These should be further validated in SARS survivors and used for vaccine formulation. We suggest that immunobioinformatics may become a fast and valuable tool in rational vaccine design.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.