ArticleDigestive diseases and sciences2004
A nitrergic secretomotor neurotransmitter in the chloride secretory response to serotonin.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.Molecular and cellular biochemistry · 2022Review
- Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.British journal of pharmacology · 2010Article
- Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea.The American journal of pathology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The neural secretory response to serotonin is mediated by enteric nerve-based 5-HT3 receptors via a nonadrenergic, noncholinergic neurotransmitter. We hypothesize that nitric oxide (NO) is this neurotransmitter, acting through cGMP at the secretory cell level to induce chloride secretion in the rat distal colon. Chambered colon was exposed to the 5-HT3 agonist, 2-methyl-5-HT, in the presence and absence of potent neural nitric oxide synthase (nNOS) inhibitors, quantifying changes in short-circuit current (delta I(SC)). Isotopic chloride efflux was measured in isolated colonocytes treated with a NO* donor (DNO) or cGMP analogue in the presence and absence of a guanylyl cyclase antagonist. Cyclic GMP production was quantified in both models. Pretreatment with potent nNOS antagonists significantly reduced the concentration-dependent 2-methyl-5-HT-induced delta I(SC). 2-Methyl-5-HT caused significant cGMP production. DNO induced cGMP production and cGMP-dependent chloride efflux in colonocyte populations. These data indicate that NO is a secretomotor neurotransmitter in response to serotonin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.