ArticleAntimicrobial agents and chemotherapy1992
Parasiticidal effect of clindamycin on Toxoplasma gondii grown in cultured cells and selection of a drug-resistant mutant.
Article in Antimicrobial agents and chemotherapy, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- The Experimental Role of Medicinal Plants in Treatment of Toxoplasma gondii Infection: A Systematic Review.Acta parasitologica · 2021Pooled it
- Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity.BMC complementary medicine and therapies · 2022Article
- Systematic Analysis of Clemastine, a Candidate Apicomplexan Parasite-Selective Tubulin-Targeting Agent.International journal of molecular sciences · 2021Article
- Toxoplasmosis: Current and Emerging Parasite Druggable Targets.Microorganisms · 2021Review
- Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma.PLoS pathogens · 2021Article
- Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.PLoS biology · 2019Article
- Discovery of Novel Anti-cryptosporidial Activities From Natural Products byFrontiers in microbiology · 2019Article
- Drug Resistance inFrontiers in microbiology · 2018Review
- Drugs in development for toxoplasmosis: advances, challenges, and current status.Drug design, development and therapy · 2017Review
- Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum.Scientific reports · 2016Article
- Anti-Toxoplasma activity and impact evaluation of lyophilization, hot molding process, and gamma-irradiation techniques on CLH-PLGA intravitreal implants.Journal of materials science. Materials in medicine · 2016Article
- Article
- Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study.Apoptosis : an international journal on programmed cell death · 2013Article
- A Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection.Molecular microbiology · 2011Article
- Lower respiratory tract infections in cats: reaching beyond empirical therapy.Journal of feline medicine and surgery · 2011Review
- Chemistry and biology of macrolide antiparasitic agents.Journal of medicinal chemistry · 2011Article
- Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis.PLoS pathogens · 2011Article
- Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49.Bioinformation · 2011Article
- Development of forward genetics in Toxoplasma gondii.International journal for parasitology · 2009Review
- Toxoplasma gondii: 25 years and 25 major advances for the field.International journal for parasitology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clindamycin, which has been reported to have no significant in vitro activity against Toxoplasma gondii, actually markedly inhibits the growth of this parasite in infected human fibroblasts. When measured 3 days after treatment, the concentration required to reduce parasite growth by 50% is about 1 ng/ml. Some observers failed to note this inhibition because of its markedly delayed onset. At 6 ng/ml, clindamycin is parasiticidal, and the rate and extent of parasite killing increase with higher drug concentrations. With the aid of chemical mutagenesis, we isolated a parasite mutant that is approximately 100-fold more resistant to clindamycin than is the wild type. Lincomycin inhibits T. gondii at a higher 50% inhibitory concentration, about 100 ng/ml. The clindamycin-resistant mutant is partially cross-resistant to lincomycin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.