ArticleHistochemistry and cell biology2004
Expression of P2Y1 receptors in rat taste buds.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- An update on extra-oral bitter taste receptors.Journal of translational medicine · 2021Review
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- Optogenetic Activation of Type III Taste Cells Modulates Taste Responses.Chemical senses · 2020Article
- Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21).Chemical senses · 2018Article
- Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells.Pflugers Archiv : European journal of physiology · 2016Article
- Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.Pflugers Archiv : European journal of physiology · 2016Article
- Article
- Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities.Chemical senses · 2015Article
- Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.The Journal of physiology · 2015Article
- Article
- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
- Role of the ectonucleotidase NTPDase2 in taste bud function.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable.Journal of cell science · 2012Article
- Article
- Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.Investigative ophthalmology & visual science · 2011Article
- Sensing via intestinal sweet taste pathways.Frontiers in neuroscience · 2011Article
- Purinergic mechanosensory transduction and visceral pain.Molecular pain · 2009Review
- Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Functional expression of ionotropic purinergic receptors on mouse taste bud cells.The Journal of physiology · 2007Article
- Afferent neurotransmission mediated by hemichannels in mammalian taste cells.The EMBO journal · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Extracellular nucleotides such as ATP are the signaling molecules which bind to membrane receptors (P2X ligand-gated ion channels and G-protein-coupled P2Y families). In the gustatory system, it is known that P2X receptors are expressed exclusively in nerve fibers innervating the taste buds. Also, P2Y receptors are suggested to play some important roles in taste signal transductions on the basis of the physiological studies. In the present study, we examined the expression patterns of P2Y1 receptor subtype by using reverse transcript polymerase chain reaction (RT-PCR), in situ hybridization, and immunohistochemistry. RT-PCR analyses showed that P2Y1 receptor mRNAs appeared in circumvallate papillae. P2Y1 receptor mRNA was detected in a subset of taste bud cells by in situ hybridization. By immunohistochemical analyses, P2Y1 receptor was detected in a subset of taste bud cells of fungiform, foliate, and circumvallate papillae. We showed that ATP induced a biphasic intracellular Ca2+ increase in taste cells by a Ca2+ imaging method. Furthermore, we showed by double-immunolabeling methods that P2Y1-expressing cells coexpressed both IP3R3 and SNAP-25. These results suggest that ATP may activate P2Y receptors resulting in Ca2+ release from internal stores via IP3R3. Since many SNAP-25-immunoreactive taste bud cells coexpressed P2Y1 immunoreactivity, it is suggested that P2Y1-expressing cells may possess synapses with afferent nerve fibers. The results of the present study suggest that P2Y1 receptor may play some roles in ATP-mediated signal transductions between taste bud cells and afferent taste fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.