Evidence map›Paper›PMID 15103025›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2004

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system.

Lingyun Wu, M Hossein Noyan Ashraf, Marina Facci, Rui Wang, Phyllis G Paterson, Alison Ferrie, Bernhard H J Juurlink

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00252018 (The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease.), which is not on this map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00252018 nacompletednot on this mapstarted 2006, after this paper: background citation

The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease.

TypeinterventionalSponsorBispebjerg HospitalRan2006 to 2007Enrolled160ConditionsDiabetes Mellitus, Hypertension, Hypercholesterolemia, Cardiovascular DiseaseArmsDaily intake of broccoli sprouts
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 283 citations in OpenAlex.

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  15. Functional foods and their impact on health.Journal of food science and technology · 2023
    Review
  16. Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment.International journal of biological sciences · 2023
    Review
  17. Broccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats.International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lingyun WuDepartment of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.
M Hossein Noyan Ashraf
Marina Facci
Rui Wang
Phyllis G Paterson
Alison Ferrie
Bernhard H J Juurlink
University of Saskatchewan · CAPlant Biotechnology Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imbalance between production and scavenging of superoxide anion results in hypertension by the inactivation of nitric oxide, and the increased oxidative stress from the resultant peroxynitrite that is produced promotes inflammatory processes such as atherosclerosis. Induction of phase 2 proteins promotes oxidant scavenging. We hypothesized that intake of dietary phase 2 protein inducers would ameliorate both hypertension and atherosclerotic changes in the spontaneously hypertensive stroke-prone rat. For 5 days/week for 14 weeks, we fed rats 200 mg/day of dried broccoli sprouts that contained glucoraphanin, which is metabolized into the phase 2 protein-inducer sulforaphane (Group A), sprouts in which most of the glucoraphanin was destroyed (Group B), or no sprouts (Group C). After 14 weeks of treatment, no significant differences were seen between rats in Groups B and C. Rats in Group A had significantly decreased oxidative stress in cardiovascular and kidney tissues, as shown by increased glutathione (GSH) content and decreased oxidized GSH, decreased protein nitrosylation, as well as increased GSH reductase and GSH peroxidase activities. Decreased oxidative stress correlated with better endothelial-dependent relaxation of the aorta and significantly lower (20 mm Hg) blood pressure. Tissues from Groups B and C had considerable numbers of infiltrating activated macrophages, indicative of inflammation, whereas animals in Group A had few detectable infiltrating macrophages. There is interest in dietary phase 2 protein inducers as means of reducing cancer incidence. We conclude that a diet containing phase 2 protein inducers also reduces the risk of developing cardiovascular problems of hypertension and atherosclerosis.

Indexed as

AnimalsBrassicaCardiovascular DiseasesGlucoseGlucosinolatesGlutathioneHypertensionImidoestersInflammationMacrophagesMaleNF-kappa BOxidative StressOximesRatsSulfoxidesglucoraphaninGlucoseGlucosinolatesGlutathioneImidoestersNF-kappa BOximesSulfoxides

Identifiers

PMID15103025
PMCPMC406471
OpenAlexW2050422509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.