ArticleProceedings of the National Academy of Sciences of the United States of America2004
Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Enhancing recognition and interpretation of functional phenotypic sequences through fine-tuning pre-trained genomic models.Journal of translational medicine · 2024Article
- The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex.Nucleic acids research · 2020Article
- Anti-Transcription Factor RNA Aptamers as Potential Therapeutics.Nucleic acid therapeutics · 2016Review
- An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Nucleic acid therapeutics · 2015Article
- Inhibition of Rift Valley fever virus replication and perturbation of nucleocapsid-RNA interactions by suramin.Antimicrobial agents and chemotherapy · 2014Article
- In search of novel drug target sites on estrogen receptors using RNA aptamers.Nucleic acid therapeutics · 2014Article
- Selection and characterization of a DNA aptamer that can discriminate between cJun/cJun and cJun/cFos.PloS one · 2014Article
- Article
- A systematic study of the features critical for designing a high avidity multivalent aptamer.Nucleic acid therapeutics · 2013Article
- Non-coding RNAs: key regulators of mammalian transcription.Trends in biochemical sciences · 2012Review
- RNA aptamers that functionally interact with green fluorescent protein and its derivatives.Nucleic acids research · 2012Article
- An RNA-based transcription activator derived from an inhibitory aptamer.Nucleic acids research · 2010Article
- Commandeering a biological pathway using aptamer-derived molecular adaptors.Nucleic acids research · 2010Article
- TFIIB aptamers inhibit transcription by perturbing PIC formation at distinct stages.Nucleic acids research · 2008Article
- Immediate-early and delayed primary response genes are distinct in function and genomic architecture.The Journal of biological chemistry · 2007Article
- RNA aptamers directed to discrete functional sites on a single protein structural domain.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A mathematical analysis of SELEX.Computational biology and chemistry · 2007Article
- An RNA aptamer that interferes with the DNA binding of the HSF transcription activator.Nucleic acids research · 2006Article
- Distinct transcriptional responses of RNA polymerases I, II and III to aptamers that bind TBP.Nucleic acids research · 2005Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The TATA-binding protein (TBP) is a critical general transcription factor that associates with the core promoter and acts as a nexus for gene regulation through its interactions with other factors. A large number of proteins recognize the relatively small yet highly conserved C-terminal domain of TBP. One subset of these proteins (general transcription factors) interacts with the TBP.TATA complex and RNA polymerase II to create the preinitiation complex. To study TBP functions in preinitiation complex and other complexes, we generated a set of RNA aptamers with high affinity to yeast TBP. These aptamers act on TBP in different ways: all of them bind TBP competitively with DNA bearing the TATA element, and some can actively disrupt the TBP.TATA interaction in preformed, higher-order complexes containing the additional general transcription factors TFIIB and TFIIA. In crude cell extracts, the aptamers inhibit transcription in ways that reveal the dynamic nature of TBP interactions during initiation and reinitiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.