ArticleProceedings of the National Academy of Sciences of the United States of America2004
Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 90 citations in OpenAlex.
- Influence of extracellular magnesium ions on the functional state and biophysical and structural properties of connexin36 hemichannels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cerebellar Transcranial Alternating Current Stimulation in Essential Tremor Patients with Thalamic Stimulation: A Proof-of-Concept Study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor.Frontiers in systems neuroscience · 2022Article
- Quasiperiodic rhythms of the inferior olive.PLoS computational biology · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library.Brain structure & function · 2019Article
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.PLoS computational biology · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Emerging strategies in the management of essential tremor.Therapeutic advances in neurological disorders · 2017Review
- Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII.Frontiers in cellular neuroscience · 2017Article
- RNA interference of GluN1 inhibits neuronal rhythmogenesis in the adult inferior olive.Journal of molecular neuroscience : MN · 2015Article
- Two functionally distinct networks of gap junction-coupled inhibitory neurons in the thalamic reticular nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Behavioral correlates of complex spike synchrony in cerebellar microzones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Treatment of essential tremor with long-chain alcohols: still experimental or ready for prime time?Tremor and other hyperkinetic movements (New York, N.Y.) · 2014Article
- Coherence and frequency in the reticular activating system (RAS).Sleep medicine reviews · 2013Review
- Requirement of neuronal connexin36 in pathways mediating presynaptic inhibition of primary afferents in functionally mature mouse spinal cord.The Journal of physiology · 2012Article
- Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2012Article
- Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Inferior olive (IO) neurons are electrically coupled by cytosolic pores formed by the neuron-specific connexin 36 (Cx36). Electrical coupling in the IO figures prominently in current views about brain control of movement. However, a role for Cx36 in movement has been questioned and not definitively demonstrated. Previous reports have shown that embryonic deletion of the Cx36 gene resulted in almost complete loss of cytosolic and electrical coupling in the IO without an obvious deficit in movement, possibly due to developmental compensations in ionic conductances that can confound the approach of embryonic gene deletion. We used a replication-incompetent lentiviral vector to stably express a dominant-negative Cx36 mutant in the IO of adult rats. We show that interneuronal cytosolic coupling is severely reduced by the mutant Cx36, without effect on neuron morphology or electrical properties. Multisite electromyography revealed that blocking Cx36 in the IO impaired the coherence of muscle firing during harmaline tremor without affecting its rhythm. The data demonstrate that gap junction coupling within the IO mediated by Cx36 adds 10-20 ms of precision to the fine temporal coordination of muscle firing during movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.