ArticleProceedings of the National Academy of Sciences of the United States of America2004
An orderly retreat: Dedifferentiation is a regulated process.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development.Communications biology · 2026Article
- Prestalk-like positioning of de-differentiated cells in the social amoeba Dictyostelium discoideum.Scientific reports · 2024Article
- Transcriptional milestones inGenome research · 2021Article
- Article
- Salivary Duct Carcinoma of the Parotid Gland Originating from an Epithelial-Myoepithelial Carcinoma: Report of a Rare Case.Head and neck pathology · 2020Article
- Palatal Polymorphous Adenocarcinoma with High-Grade Transformation: A Case Report and Literature Review.Head and neck pathology · 2019Article
- The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium.Journal of cell science · 2016Article
- Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells.Scientific reports · 2015Article
- The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.Nature communications · 2015Article
- Dedifferentiated endometrioid adenocarcinoma of the uterus: highly aggressive and poor prognostic tumor.Korean journal of pathology · 2014Article
- Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: the role of immunomarkers in diagnosis.BMJ case reports · 2013Article
- Understanding cancer stem cell heterogeneity and plasticity.Cell research · 2012Review
- BzpF is a CREB-like transcription factor that regulates spore maturation and stability in Dictyostelium.Developmental biology · 2011Article
- Cell type-specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.Development (Cambridge, England) · 2011Article
- Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors.Pathology research international · 2011Article
- New components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data.BMC bioinformatics · 2010Article
- dictyExpress: a Dictyostelium discoideum gene expression database with an explorative data analysis web-based interface.BMC bioinformatics · 2009Article
- Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.Carcinogenesis · 2009Article
- Developmental commitment in Dictyostelium discoideum.Eukaryotic cell · 2007Article
- Global transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Differentiation is a highly regulated process whereby cells become specialized to perform specific functions and lose the ability to perform others. In contrast, the question of whether dedifferentiation is a genetically determined process, or merely an unregulated loss of the differentiated state, has not been resolved. We show here that dedifferentiation in the social amoeba Dictyostelium discoideum relies on a sequence of events that is independent of the original developmental state and involves the coordinated expression of a specific set of genes. A defect in one of these genes, the histidine kinase dhkA, alters the kinetics of dedifferentiation and uncouples the progression of dedifferentiation events. These observations establish dedifferentiation as a genetically determined process and suggest the existence of a developmental checkpoint that ensures a return path to the undifferentiated state.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.