ArticleInfection and immunity2004
Functional transfer of Salmonella pathogenicity island 2 to Salmonella bongori and Escherichia coli.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Cytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling.Cell communication and signaling : CCS · 2024Article
- Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes.PLoS biology · 2024Article
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- Updated review on immune factors in pathogenesis of Crohn's disease.World journal of gastroenterology · 2018Review
- The Type III Secretion System Effector SeoC of Salmonella enterica subsp. salamae and S. enterica subsp. arizonae ADP-Ribosylates Src and Inhibits Opsonophagocytosis.Infection and immunity · 2016Article
- Real-time optotracing of curli and cellulose in liveNPJ biofilms and microbiomes · 2016Article
- The N terminus of type III secretion needle protein YscF from Yersinia pestis functions to modulate innate immune responses.Infection and immunity · 2015Article
- Characterization of Salmonella type III secretion hyper-activity which results in biofilm-like cell aggregation.PloS one · 2012Article
- Salmonella bongori provides insights into the evolution of the Salmonellae.PLoS pathogens · 2011Article
- Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family.The EMBO journal · 2011Article
- Prokaryotic gene clusters: a rich toolbox for synthetic biology.Biotechnology journal · 2010Review
- Thioredoxin 1 participates in the activity of the Salmonella enterica serovar Typhimurium pathogenicity island 2 type III secretion system.Journal of bacteriology · 2009Article
- Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Differentially evolved genes of Salmonella pathogenicity islands: insights into the mechanism of host specificity in Salmonella.PloS one · 2008Article
- Cloning and transfer of the Salmonella pathogenicity island 2 type III secretion system for studies of a range of gram-negative genera.Applied and environmental microbiology · 2007Article
- SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system.Infection and immunity · 2007Article
- A new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns.BMC evolutionary biology · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type III secretion system (T3SS) encoded by the Salmonella pathogenicity island 2 (SPI2) has a central role in systemic infections by Salmonella enterica and for the intracellular phenotype. Intracellular S. enterica uses the SPI2-encoded T3SS to translocate a set of effector proteins into the host cell, which modify host cell functions, enabling intracellular survival and replication of the bacteria. We sought to determine whether specific functions of the SPI2-encoded T3SS can be transferred to heterologous hosts Salmonella bongori and Escherichia coli Mutaflor, species that lack the SPI2 locus and loci encoding effector proteins. The SPI2 virulence locus was cloned and functionally expressed in S. bongori and E. coli. Here, we demonstrate that S. bongori harboring the SPI2 locus is capable of secretion of SPI2 substrate proteins under culture conditions, as well as of translocation of effector proteins under intracellular conditions. An SPI2-mediated cellular phenotype was induced by S. bongori harboring the SPI2 if the sifA locus was cotransferred. An interference with the host cell microtubule cytoskeleton, a novel SPI2-dependent phenotype, was observed in epithelial cells infected with S. bongori harboring SPI2 without additional effector genes. S. bongori harboring SPI2 showed increased intracellular persistence in a cell culture model, but SPI2 transfer was not sufficient to confer to S. bongori systemic pathogenicity in a murine model. Transfer of SPI2 to heterologous hosts offers a new tool for the study of SPI2 functions and the phenotypes of individual effectors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.