ArticleInfection and immunity2004
Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates.PLoS neglected tropical diseases · 2025Article
- The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode.BMC biology · 2024Article
- A dominance of Mu class glutathione transferases within the equine tapewormParasitology · 2024Article
- Mining gene expression data for rational identification of novel drug targets and vaccine candidates against the cattle tick, Rhipicephalus microplus.Experimental & applied acarology · 2023Article
- Identification and characterisation of the haemozoin of Haemonchus contortus.Parasites & vectors · 2023Article
- One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.Biochimica et biophysica acta. Molecular cell research · 2021Review
- Hc-hrg-2, a glutathione transferase gene, regulates heme homeostasis in the blood-feeding parasitic nematode Haemonchus contortus.Parasites & vectors · 2020Article
- Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults.PLoS neglected tropical diseases · 2017Article
- Characterisation of Dermanyssus gallinae glutathione S-transferases and their potential as acaricide detoxification proteins.Parasites & vectors · 2015Article
- The same or not the same: lineage-specific gene expansions and homology relationships in multigene families in nematodes.Journal of molecular evolution · 2015Article
- The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus.Genome biology · 2013Article
- One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.Biochimica et biophysica acta · 2012Review
- Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme-responsive gene-2.The Journal of biological chemistry · 2012Article
- Proteomic profiling and protein identification by MALDI-TOF mass spectrometry in unsequenced parasitic nematodes.PloS one · 2012Article
- Developing vaccines to combat hookworm infection and intestinal schistosomiasis.Nature reviews. Microbiology · 2010Review
- Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans.PLoS genetics · 2010Article
- Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus.Infection and immunity · 2010Article
- Enzymatic antioxidant systems in helminth parasites.Parasitology research · 2009Review
- Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phase II detoxification system glutathione transferase (GST) is associated with the establishment of parasitic nematode infections within the gastrointestinal environment of the mammalian host. We report the functional analysis of a GST from an important worldwide parasitic nematode of small ruminants, Haemonchus contortus. This GST shows limited activity with a range of classical GST substrates but effectively binds hematin. The high-affinity binding site for hematin was not present in the GST showing the most identity, CE07055 from the free-living nematode Caenorhabditis elegans. This finding suggests that the high-affinity binding of hematin may represent a parasite adaptation to blood or tissue feeding from the host.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.