ArticleInfection and immunity2004
Impairment of tetanus-specific cellular and humoral responses following tetanus vaccination in human lymphatic filariasis.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Effect of Schistosoma mansoni infection and its treatment on antibody responses to measles catch-up immunisation in pre-school children: A randomised trial.PLoS neglected tropical diseases · 2019Trial
- Trial
- A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study).BMC infectious diseases · 2011Trial
- Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.Lancet (London, England) · 2011Trial
- The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.Journal of immunology (Baltimore, Md. : 1950) · 2007Trial
- Microfilaremic loiasis is associated with T cell hyporesponsiveness against SARS-CoV-2.PLoS neglected tropical diseases · 2026Article
- Humoral immune response to COVID-19 vaccines in onchocerciasis-infected individuals: a field study from Ghana.Frontiers in immunology · 2025Article
- Antibody response after feline panleukopenia virus vaccination in kittens with and without intestinal parasites.Journal of feline medicine and surgery · 2024Article
- Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2.bioRxiv : the preprint server for biology · 2024Article
- Intestinal Helminth Infection Impairs Oral and Parenteral Vaccine Efficacy.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Strongyloides and COVID-19: Challenges and Opportunities for Future Research.Tropical medicine and infectious disease · 2023Review
- Immunomodulation of COVID-19 severity by helminth co-infection: Implications for COVID-19 vaccine efficacy.Immunity, inflammation and disease · 2022Review
- Impact of Helminth Infections on Female Reproductive Health and Associated Diseases.Frontiers in immunology · 2020Review
- Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines? Systems Biology Views of Vaccine Innate and Adaptive Immunity.Cold Spring Harbor perspectives in biology · 2018Review
- Lymph node fibrosis: a structural barrier to unleashing effective vaccine immunity.The Journal of clinical investigation · 2018Article
- Assessment of novel vaccination regimens using viral vectored liver stage malaria vaccines encoding ME-TRAP.Scientific reports · 2018Article
- Regulatory T Cells Mediate Local Immunosuppression in Lymphedema.The Journal of investigative dermatology · 2018Article
- Human innate lymphoid cells (ILCs) in filarial infections.Parasite immunology · 2018Review
- Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
To investigate the consequences of the impaired parasite-specific immune response in lymphatic filariasis, the effect of concurrent Wuchereria bancrofti infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied in 20 asymptomatic microfilaremic (MF) patients, 20 patients with chronic lymphatic obstruction/elephantiasis (chronic pathology [CP]), and 10 endemic normal (EN) control individuals at baseline and at 3 and 6 months after TT vaccination. Peripheral blood mononuclear cell (PBMC) proliferative responses to TT before vaccination were not significantly different between the EN control and CP groups, but the MF group showed significantly lower baseline proliferative responses to TT compared with either the EN or CP group. Six months following vaccination, the change in proliferative response to TT was significantly greater in the EN and CP groups than in the MF group. This difference in proliferative response was reiterated in the gamma interferon (IFN-gamma) response in the EN group, in that they increased IFN-gamma production by 400% at 6 months, in contrast to that seen in the filaria-infected groups. In contrast to the IFN-gamma responses, PBMCs from the MF group produced significantly increased levels of TT-specific IL-10 compared with PBMCs from the EN group. Although there was significantly greater TT-specific immunoglobulin G (IgG) production at baseline between the EN and MF groups, postvaccination IgG (and IgG1 isotype) responses did not differ among the groups, whereas TT-specific IgG2, IgG3, and IgG4 were all increased in the EN group compared with the filaria-infected groups. These studies indicate that concurrent infection with W. bancrofti can diminish the immune response to an unrelated antigen by a mechanism that is likely to involve IL-10.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.