ArticleArchives of disease in childhood. Fetal and neonatal edition2004
Perinatal pathology in the context of a clinical trial: attitudes of neonatologists and pathologists.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Factors affecting uptake of postmortem examination in the prenatal, perinatal and paediatric setting.BJOG : an international journal of obstetrics and gynaecology · 2018Pooled it
- Pooled it
- Maternity Healthcare Chaplains and Perinatal Post-Mortem Support and Understanding in the United Kingdom and Ireland: An Exploratory Study.Journal of religion and health · 2021Article
- Decision influences and aftermath: parents, stillbirth and autopsy.Health expectations : an international journal of public participation in health care and health policy · 2014Article
- Altruism in terminal cancer patients and rapid tissue donation program: does the theory apply?Medicine, health care, and philosophy · 2013Article
- The use of in utero MRI to supplement ultrasound in the foetus at high risk of developmental brain or spine abnormality.The British journal of radiology · 2012Article
- The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials.Trials · 2010Article
- Current techniques in postmortem imaging with specific attention to paediatric applications.Pediatric radiology · 2010Review
- Perinatal and infant autopsy.Archives of disease in childhood. Fetal and neonatal edition · 2007Article
- Perinatal pathology in the context of a clinical trial: a review of the literature.Archives of disease in childhood. Fetal and neonatal edition · 2004Review
- Perinatal pathology in the context of a clinical trial: attitudes of bereaved parents.Archives of disease in childhood. Fetal and neonatal edition · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the attitudes of neonatologists to trial related perinatal postmortem examinations (PMs), in the light of declining perinatal PM rates and poor levels of participation in pathology studies.
methodsA qualitative study was carried out, using semistructured interviews. Twenty six neonatologists from five UK neonatal units were interviewed; five UK perinatal pathologists also contributed to the study. The professionals involved were all linked to one or both of two neonatal trials.
resultsPathologists expressed concern over the difficulties experienced in UK perinatal pathology and the impact on research of inadequate levels of samples. The interviews with neonatologists reveal discomfort over approaching bereaved parents for PMs, and a widespread concern that parents should not be further distressed or feel under pressure to consent. Although there was support for neonatal trials, the study highlights a view that PMs may be unnecessary if the cause of death seems apparent or when a baby was born prematurely, and a devaluation of PMs among some younger staff. Poor rates of participation in pathology studies may be accounted for by a notable sense of disconnection between trial interventions and pathology studies.
conclusionsNeonatologists were concerned to protect vulnerable parents and varied in whether they saw this as compatible with inclusion in trial related pathology studies. Dedicated research is needed to document and gain an understanding of the consent process and should examine the usefulness and impact of consent forms. It should assess whether professionals might benefit from training, to help parents to come to their decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.