Evidence map›Paper›PMID 15102630›Full record

ArticleArchives of disease in childhood2004

Changes in the atherogenic risk factor profile according to degree of weight loss.

T Reinehr, W Andler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of disease in childhood, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 4 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Pooled it
  2. Interventions for preventing obesity in children.The Cochrane database of systematic reviews · 2019
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  4. [Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016
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  10. Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

T ReinehrDepartment of Vestische Kinderklinik, University of Witten-Herdecke, Datteln, Germany. T.Reinehr@kinderklinik-datteln.de
W Andler
Witten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe atherogenic risk factor profile in obese subjects is characterised by hypertension, reduced high density lipoprotein (HDL) cholesterol, increased low density lipoprotein (LDL) cholesterol and triglycerides, and insulin resistance.

aimsTo examine the amount of weight reduction required to improve the atherogenic profile.

methodsChanges of systolic and diastolic blood pressure, HDL and LDL cholesterol, triglycerides, and insulin resistance, based on the HOMA model over a one year period were studied in obese children, who attended the intervention programme "Obeldicks". The children were divided into four groups according to the change in body mass index standard deviation score (SDS-BMI): group I, increase in SDS-BMI; group II, decrease in SDS-BMI <0.25; group III, decrease in SDS-BMI > or =0.25-<0.5; group IV, decrease in SDS-BMI > or =0.5.

resultsA total of 130 children (mean age 10.7 years, range 4-15; mean SDS-BMI 2.5, range 2.0-4.0) were studied. The four groups did not differ in age, gender, or degree of overweight (SDS-BMI). An increasing SDS-BMI (group I: n = 20) was followed by a significant increase in insulin resistance (HOMA). Systolic and diastolic blood pressure, LDL cholesterol, triglycerides, and insulin resistance (HOMA) decreased significantly while HDL cholesterol increased significantly in group IV (n = 37). LDL cholesterol also decreased significantly in group III (n = 40); there was no significant change of the other parameters in groups I, II, and III.

conclusionOver a time period of one year increasing weight in obese children leads to an increase in insulin resistance. Weight loss is associated with an improvement in the atherogenic profile and in insulin resistance, but only if the SDS-BMI decreases by at least 0.5 over a one year period.

Indexed as

AdolescentArteriosclerosisBlood PressureBody Mass IndexChildChild, PreschoolCholesterol, HDLCholesterol, LDLFemaleHumansInsulin ResistanceMaleObesityRisk FactorsTriglyceridesWeight LossCholesterol, HDLCholesterol, LDLTriglycerides

Identifiers

PMID15102630
PMCPMC1719907
OpenAlexW2075104837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.