Trial reportEuropean journal of clinical nutrition2004
Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects.
Trial report in European journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Pooled it
- Trial
- Fish oil supplementation does not lower C-reactive protein or interleukin-6 levels in healthy adults.Journal of internal medicine · 2016Trial
- Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome.The Journal of nutrition · 2011Trial
- Trial
- No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals.European journal of clinical nutrition · 2009Trial
- DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men.The Journal of nutrition · 2009Trial
- Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease.European journal of clinical nutrition · 2006Trial
- Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort.The Journal of clinical endocrinology and metabolism · 2025Article
- Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study.Nutrients · 2019Article
- Fish Oil Supplementation Reduces Inflammation but Does Not Restore Renal Function and Klotho Expression in an Adenine-Induced CKD Model.Nutrients · 2018Article
- Review of Cardiometabolic Effects of Prescription Omega-3 Fatty Acids.Current atherosclerosis reports · 2017Review
- Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins.Nutrients · 2016Review
- The use of dietary supplements to alleviate androgen deprivation therapy side effects during prostate cancer treatment.Nutrients · 2014Review
- Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial.Journal of periodontal & implant science · 2014Article
- Unraveling the complex relationship triad between lipids, obesity, and inflammation.Mediators of inflammation · 2014Review
- Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review.Food & nutrition research · 2014Review
- Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes.Journal of nutrition & food sciences · 2013Article
- Nutritional properties of dietary omega-3-enriched phospholipids.BioMed research international · 2013Review
- Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men.European journal of clinical nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, is a powerful predictor of cardiovascular risk. We hypothesised that n-3 fatty acids reduce underlying inflammatory processes and consequently CRP concentrations in healthy middle-aged subjects.
designPlacebo-controlled, double-blind study. SUBJECTS: A total of 43 men and 41 postmenopausal women aged 50-70 y. Before and after intervention, we measured serum CRP concentrations with an enzyme immunoassay.
interventionsCapsules with either 3.5 g/day fish oil (1.5 g/day n-3 fatty acids) or placebo for 12 weeks.
resultsThe median CRP change in the fish oil group did not significantly differ from that in the placebo group (0.01 vs -0.17 mg/l, P = 0.057).
conclusionThe currently available data--including ours--do not support that beneficial effects on CRP are involved in a mechanism explaining the protective effect on heart disease risk of n-3 fatty acids as present in fish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.