ArticleRNA (New York, N.Y.)2004
tRNA slippage at the tmRNA resume codon.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis.RNA biology · 2015Article
- Alternative fates of paused ribosomes during translation termination.The Journal of biological chemistry · 2011Article
- Visualizing the transfer-messenger RNA as the ribosome resumes translation.The EMBO journal · 2010Article
- A role for the 30S subunit E site in maintenance of the translational reading frame.RNA (New York, N.Y.) · 2009Article
- Escherichia coli tmRNA lacking pseudoknot 1 tags truncated proteins in vivo and in vitro.RNA (New York, N.Y.) · 2009Article
- Preferred and avoided codon pairs in three domains of life.BMC genomics · 2008Article
- Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genetic analysis of the E site during RF2 programmed frameshifting.RNA (New York, N.Y.) · 2007Article
- An extended signal involved in eukaryotic -1 frameshifting operates through modification of the E site tRNA.Molecular cell · 2005Article
- Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu.Nucleic acids research · 2005Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe bacterial ribosome does not initiate translation on the mRNA portion of tmRNA; instead translation that had begun on a separate mRNA molecule resumes at a particular triplet on tmRNA (the resume codon). For at least two tRNAs that could pair with both the resume and -2 triplets on mutant tmRNAs, UAA (stop) as the second codon induced high-frequency -2 slippage on the resume codon in the P site. The frameshift product was not detected when the -2 base was altered. Deficiency for ribosomal L9 protein, which affects other cases of frameshifting, had no significant effect. A special feature of this frameshifting is its dependence on a particular context, that of the tmRNA resume codon; it failed on the same sequence in a regular mRNA, and, more strikingly, at the second tmRNA codon. This focuses attention on the peculiar features expected of the slippage-prone state, such as unusual E-site filling, that might make the P-site resume codon:anticodon interaction especially unstable. KEYWORDS: tmRNA; ribosome; frameshift; E site; translation
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.