ArticleProceedings of the National Academy of Sciences of the United States of America2004
Theoretical basis for genetic linkage analysis in autotetraploid species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Autotetraploid Origin of Chinese Cherry Revealed by Chromosomal Karyotype and In Situ Hybridization of Seedling Progenies.Plants (Basel, Switzerland) · 2023Article
- Article
- The recombination landscape and multiple QTL mapping in a Solanum tuberosum cv. 'Atlantic'-derived FHeredity · 2021Article
- A tetrasomic inheritance model and likelihood-based method for mapping quantitative trait loci in autotetraploid species.The New phytologist · 2021Article
- Genome Duplication Increases Meiotic Recombination Frequency: A Saccharomyces cerevisiae Model.Molecular biology and evolution · 2021Article
- Unraveling the Hexaploid Sweetpotato Inheritance Using Ultra-Dense Multilocus Mapping.G3 (Bethesda, Md.) · 2020Article
- High-Resolution Linkage Map With Allele Dosage Allows the Identification of Regions Governing Complex Traits and Apospory in Guinea Grass (Frontiers in plant science · 2020Article
- Linkage Analysis and Haplotype Phasing in Experimental Autopolyploid Populations with High Ploidy Level Using Hidden Markov Models.G3 (Bethesda, Md.) · 2019Article
- Quantifying the Power and Precision of QTL Analysis in Autopolyploids Under Bivalent and Multivalent Genetic Models.G3 (Bethesda, Md.) · 2019Article
- Article
- Article
- PERGOLA: fast and deterministic linkage mapping of polyploids.BMC bioinformatics · 2017Article
- Genetic mapping with an inbred line-derived F2 population in potato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Article
- Genetic Linkage Mapping of Economically Important Traits in Cultivated Tetraploid Potato (Solanum tuberosum L.).G3 (Bethesda, Md.) · 2015Article
- Improving breeding efficiency in potato using molecular and quantitative genetics.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Review
- Article
- Polyploidization increases meiotic recombination frequency in Arabidopsis: a close look at statistical modeling and data analysis.BMC biology · 2012Article
- Response to Wang and Luo.BMC biology · 2012Article
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3 authors.
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Abstract
Linkage analysis in autotetraploid species has been an historical challenge in quantitative genetics theory and is a stumbling block that urgently needs to be removed in the rapidly emerging genome research on this species, such as cultivated potato. This article presents theory of a full model of tetrasomic linkage and develops a statistical framework for the linkage analysis. The model considers both double reduction and recombination, the most essential features of tetrasomic inheritance with linked loci, whereas the statistical method takes appropriate account of the major complexities in analyzing both dominant and codominant molecular marker data during map reconstruction in tetraploid species. These complexities include the problems arising from multiple dosage of allelic inheritance, the null allele, allelic segregation distortion, mixed bivalent and quadrivalent pairing in meiosis, and incomplete information of marker phenotype data. The theoretical analysis established the relationship between the coefficients of double reduction at linked loci, which is essential in the present tetrasomic linkage analysis and in assessing the impact of double reduction on the evolution of tetraploid populations. The statistical method, based on the combination of theoretical analysis and a computer-based algorithm, provided analytical tools for predicting the maximum-likelihood estimates of the model parameters. A simulation study showed the feasibility of a practical implementation of the method, detailed the procedure of the analysis, validated the power and reliability in the parameter estimation, and compared the present method with those proposed in the current literature.
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