ArticleNeuroscience2004
Chronic stress enhances ibotenic acid-induced damage selectively within the hippocampal CA3 region of male, but not female rats.
Article in Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity.International journal of molecular sciences · 2021Article
- Stress-induced Changes in the S-palmitoylation and S-nitrosylation of Synaptic Proteins.Molecular & cellular proteomics : MCP · 2019Article
- Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.Current psychiatry reports · 2017Review
- Hypothalamic-pituitary-adrenocortical axis dysfunction in epilepsy.Physiology & behavior · 2016Review
- Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.Neurobiology of aging · 2016Article
- Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons.The European journal of neuroscience · 2013Article
- Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses.Molecular neurobiology · 2013Article
- Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity.Experimental neurology · 2013Article
- Assessing competence of broccoli consumption on inflammatory and antioxidant pathways in restraint-induced models: estimation in rat hippocampus and prefrontal cortex.BioMed research international · 2013Article
- Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors.Neuroscience · 2011Article
- Aging and stress: past hypotheses, present approaches and perspectives.Aging and disease · 2011Article
- Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling.Annals of the New York Academy of Sciences · 2010Review
- Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus.Journal of neurophysiology · 2010Article
- Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines.Pharmacological reviews · 2010Review
- Article
- Amphetamine toxicities: classical and emerging mechanisms.Annals of the New York Academy of Sciences · 2010Review
- Chronic stress- and sex-specific neuromorphological and functional changes in limbic structures.Molecular neurobiology · 2009Review
- Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence.Neuroscience · 2009Article
- Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields.European journal of pharmacology · 2009Article
- Chronic stress and sex differences on the recall of fear conditioning and extinction.Neurobiology of learning and memory · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this investigation was to assess the ability of the hippocampus to withstand a metabolic challenge following chronic stress. An N-methyl-d-aspartate receptor excitotoxin (ibotenic acid, IBO) was infused into the CA3 region of the hippocampus following a period of restraint for 6 h/day/21 days. Following the end of restraint when CA3 dendritic retraction persists (3 to 4 days), rats were infused with IBO (or vehicle) into the CA3 region of the hippocampus. Stressed male rats showed significantly more CA3 damage after IBO infusion relative to controls and the saline-infused side. Moreover, IBO-exacerbation of damage in males was not observed in the CA3 region 3 to 4 days after acute stress (6 h restraint), nor in the CA1 region after chronic stress. Females were also examined and chronic stress did not exacerbate IBO damage in the CA3 region. Overall, these results demonstrate that chronic stress compromises the ability of the hippocampus to withstand a metabolic challenge days after the chronic stress regimen has subsided in male rats. Whether the conditions surrounding CA3 dendritic retraction in females represents vulnerability is less clear and warrants further investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.