ArticleNeurochemical research2004
S100B-mediated inhibition of the phosphorylation of GFAP is prevented by TRTK-12.
Article in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury-Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro.International journal of molecular sciences · 2026Article
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- Article
- S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate.Metabolites · 2023Article
- The Impact of High Glucose or Insulin Exposure on S100B Protein Levels, Oxidative and Nitrosative Stress and DNA Damage in Neuron-Like Cells.International journal of molecular sciences · 2021Article
- Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells.Marine drugs · 2019Article
- S100 proteins in rheumatic diseases.Nature reviews. Rheumatology · 2018Review
- Insulin Stimulates S100B Secretion and These Proteins Antagonistically Modulate Brain Glucose Metabolism.Neurochemical research · 2016Article
- Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker.Trends in neurosciences · 2015Review
- Characterization of adult rat astrocyte cultures.PloS one · 2013Article
- The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration.Neuroscience · 2011Article
- Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease.Cardiovascular psychiatry and neurology · 2010Article
- Theoretical study on binding of S100B protein.Journal of molecular modeling · 2007Article
- Calcium-dependent and -independent interactions of the S100 protein family.The Biochemical journal · 2006Review
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S100B belongs to a family of calcium-binding proteins involved in cell cycle and cytoskeleton regulation. We observed an inhibitory effect of S100B on glial fibrillary acidic protein (GFAP) phosphorylation, when stimulated by cAMP or Ca2+/calmodulin, in a cytoskeletal fraction from primary astrocyte cultures. We found that S100B has no direct effect on CaM KII activity, the major kinase in this cytoskeletal fraction able to phosphorylate GFAP. The inhibition of GFAP phosphorylation is most likely due to the binding of S100B to the phosphorylation sites on this protein and blocking the access of these sites to the protein kinases. This inhibition was dependent on Ca2+. However, Zn2+ could substitute for Ca2+. The inhibitory effect of S100B was prevented by TRTK-12, a peptide that blocks S100B interaction with several target proteins including glial fibrillary acidic protein. These data suggest a role for S100B in the assembly of intermediate filaments in astrocytes.
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