ArticleProceedings of the National Academy of Sciences of the United States of America2004
Stochastic model of protein-protein interaction: why signaling proteins need to be colocalized.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
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- A critical evaluation of protein kinase regulation by activation loop autophosphorylation.eLife · 2023Article
- Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes.Annual review of biomedical data science · 2022Review
- Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2.Chaos (Woodbury, N.Y.) · 2020Article
- Mechanisms and consequences of subcellular RNA localization across diverse cell types.Traffic (Copenhagen, Denmark) · 2020Review
- Growth, Cell Division, and Gene Expression ofMicroorganisms · 2020Article
- Prognostic Significance of Prostaglandin-Endoperoxide Synthase-2 Expressions in Human Breast Carcinoma: A Multiomic Approach.Cancer informatics · 2020Article
- The Balancing Act of Intrinsically Disordered Proteins: Enabling Functional Diversity while Minimizing Promiscuity.Journal of molecular biology · 2019Article
- CeFra-seq reveals broad asymmetric mRNA and noncoding RNA distribution profiles inRNA (New York, N.Y.) · 2018Article
- Three-Phase Coexistence in Lipid Membranes.Biophysical journal · 2017Article
- Effective molarity in a nucleic acid-controlled reaction.Bioorganic & medicinal chemistry letters · 2016Article
- How spatial heterogeneity shapes multiscale biochemical reaction network dynamics.Journal of the Royal Society, Interface · 2015Article
- Membrane microdomains: from seeing to understanding.Frontiers in plant science · 2014Review
- Article
- Entrainment of peripheral clock genes by cortisol.Physiological genomics · 2012Article
- Arbitrary protein-protein docking targets biologically relevant interfaces.BMC biophysics · 2012Article
- Translational regulation of the cell cycle: when, where, how and why?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two interacting proteins and their degradation rates become primary determinants of the time required for interaction. To understand the role of such colocalization, we create a mathematical model of the diffusion based protein-protein interaction process. We assume that mRNAs, which serve as the sources of these proteins, are located at different positions in the cytoplasm. For large cells such as Drosophila oocytes we show that if the source mRNAs were at random locations in the cell rather than colocalized, the average rate of interactions would be extremely small, which suggests that localization is needed to facilitate protein interactions and not just to prevent cross-talk between different signaling modules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.