ArticleNucleic acids research2004
The fragile X mental retardation protein has nucleic acid chaperone properties.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- A retroelement-derived mammalian ARC protein exhibits selective RNA recognition and nucleic acid chaperone functions.Nucleic acids research · 2026Article
- The RGG/RG motif of AUF1 isoform p45 is a key modulator of the protein's RNA chaperone and RNA annealing activities.RNA biology · 2019Article
- A structural perspective of RNA recognition by intrinsically disordered proteins.Cellular and molecular life sciences : CMLS · 2016Review
- Ty1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions.Nucleic acids research · 2015Article
- Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.Human molecular genetics · 2015Article
- Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders.Science signaling · 2014Review
- Alterations in the Sp1 binding and Fmr-1 gene expression in the cortex of the brain during maturation and aging of mouse.Molecular biology reports · 2014Article
- Similarities and differences in the nucleic acid chaperone activity of HIV-2 and HIV-1 nucleocapsid proteins in vitro.Retrovirology · 2014Article
- Increasing our understanding of human cognition through the study of Fragile X Syndrome.Developmental neurobiology · 2014Review
- Characterization of RNA binding and chaperoning activities of HIV-1 Vif protein. Importance of the C-terminal unstructured tail.RNA biology · 2014Article
- The FMRP regulon: from targets to disease convergence.Frontiers in neuroscience · 2013Review
- Translational control at the synapse: role of RNA regulators.Trends in biochemical sciences · 2013Review
- BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses.Nucleic acids research · 2012Article
- The pathophysiology of fragile X (and what it teaches us about synapses).Annual review of neuroscience · 2012Review
- Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.Nucleic acids research · 2011Article
- Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders.Journal of neurodevelopmental disorders · 2011Article
- Proteins with RNA chaperone activity: a world of diverse proteins with a common task-impediment of RNA misfolding.Biochemistry research international · 2011Article
- Conformational-dependent and independent RNA binding to the fragile x mental retardation protein.Journal of nucleic acids · 2011Article
- Recombinant bacterial expression and purification of human fragile X mental retardation protein isoform 1.Protein expression and purification · 2010Article
- MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases.Brain research · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fragile X syndrome is the most common cause of inherited mental retardation resulting from the absence of the fragile X mental retardation protein (FMRP). FMRP contains two K-homology (KH) domains and one RGG box that are landmarks characteristic of RNA-binding proteins. In agreement with this, FMRP associates with messenger ribonucleoparticles (mRNPs) within actively translating ribosomes, and is thought to regulate translation of target mRNAs, including its own transcript. To investigate whether FMRP might chaperone nucleic acid folding and hybridization, we analysed the annealing and strand exchange activities of DNA oligonucleotides and the enhancement of ribozyme-directed RNA substrate cleavage by FMRP and deleted variants relative to canonical nucleic acid chaperones, such as the cellular YB-1/p50 protein and the retroviral nucleocapsid protein HIV-1 NCp7. FMRP was found to possess all the properties of a potent nucleic acid chaperone, requiring the KH motifs and RGG box for optimal activity. These findings suggest that FMRP may regulate translation by acting on RNA-RNA interactions and thus on the structural status of mRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.