ArticleBMJ (Clinical research ed.)2004
Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study.
Article in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378282 (Identification of Diabetic Nephropathy Biomarkers Through Transcriptomics), which is not on this map. Cited by 141 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Diabetic Nephropathy Biomarkers Through Transcriptomics
Who cites it
141 citing papers in PubMed, 4 syntheses or guidelines pooled it, 425 citations in OpenAlex.
- Guideline
- [Early detection by urinary proteome analysis : A new concept in patient management of diabetic nephropathy].Der Internist · 2020Pooled it
- Pooled it
- Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts.Kidney international · 2011Pooled it
- Effect of Finerenone on Albuminuria in Type 1 Diabetes by Baseline HbA1c Level and Diabetes Duration: An Exploratory Analysis of the FINE-ONE Trial.Diabetes care · 2026Trial
- Trial
- Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes.Hormone research in paediatrics · 2017Trial
- Effect of intensive diabetes treatment on albuminuria in type 1 diabetes: long-term follow-up of the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study.The lancet. Diabetes & endocrinology · 2014Trial
- Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort.Archives of internal medicine · 2011Trial
- Trial
- Albuminuria Categories at Screening and Associated Clinical Factors in Adults with Type 2 Diabetes, Preserved eGFR, and No Prior Diagnosis of Diabetic Kidney Disease: An Exploratory Single-Center Cross-Sectional Study in Western Mexico.Medical sciences (Basel, Switzerland) · 2026Article
- Development of risk assessment models for microvascular complications in type 2 diabetes mellitus patients: a cross-sectional study.Scientific reports · 2026Article
- Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality.World journal of nephrology · 2026Article
- An Algorithm for Identifying Microvascular Complications in Type 1 Diabetes in the Clinical Setting: Development and External Validation.Health data science · 2026Article
- Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?Journal of clinical research in pediatric endocrinology · 2025Article
- Comprehending the Role of Metabolic and Hemodynamic Factors Alongside Different Signaling Pathways in the Pathogenesis of Diabetic Nephropathy.International journal of molecular sciences · 2025Review
- Long-term tracking of glycosylated hemoglobin levels across the lifespan in type 1 diabetes: from infants to young adults.Annals of pediatric endocrinology & metabolism · 2024Article
- Article
- Diabetes and Renal Complications: An Overview on Pathophysiology, Biomarkers and Therapeutic Interventions.Biomedicines · 2024Review
- Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin.Diabetology international · 2024Review
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate baseline predictors for the development of persistent microalbuminuria and macroalbuminuria prospectively in patients with type 1 diabetes.
designProspective observational study of an inception cohort.
settingOutpatient diabetic clinic in a tertiary referral centre, Gentofte, Denmark.
participants286 patients (216 adults) newly diagnosed with type 1 diabetes consecutively admitted to the clinic between 1 September 1979 and 31 August 1984.
main outcome measuresPersistent microalbuminuria and persistent macroalbuminuria.
resultsDuring the median follow up of 18.0 years (range 1.0-21.5 years), total of 4706 patient years of follow up, 79 of 277 (29%) patients developed persistent microalbuminuria. 27 of 79 progressed further to persistent macroalbuminuria. The cumulative incidence of persistent microalbuminuria and persistent macroalbuminuria was 33.6% (95% confidence interval 27.2% to 40.0%) and 14.6% (8.9% to 20.3%), respectively. Significant predictors for the development of persistent microalbuminuria were a 10-fold increase in urinary albumin excretion rate (relative risk 3.78, 1.57 to 9.13), being male (2.41, 1.43 to 4.06), a 10 mm Hg increase in mean arterial blood pressure (1.38, 1.20 to 1.57), a 1% increase in haemoglobin A1c (1.18, 1.04 to 1.32), and a 1 cm increase in height (0.96, 0.95 to 0.98). 28 patients with microalbuminuria (35%) regressed to normoalbuminuria either transiently (n = 15) or permanently (n = 13).
conclusionsAround one third of patients newly diagnosed with type 1 diabetes develop persistent microalbuminuria within the first 20 years of diabetes. Several potentially modifiable risk factors predict the development of persistent microalbuminaria and persistent macroalbuminuria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.