ReviewOncogene2004
An essential role for protein synthesis in oncogenic cellular transformation.
Review in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan-cancer.Molecular oncology · 2026Article
- YB-1 Is a Novel Target for the Inhibition of α-Adrenergic-Induced Hypertrophy.International journal of molecular sciences · 2023Article
- Targeting cancer via ribosome biogenesis: the cachexia perspective.Cellular and molecular life sciences : CMLS · 2021Review
- Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation.Oncotarget · 2017Article
- Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target.Journal of Cancer · 2017Review
- Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition.Molecular & cellular proteomics : MCP · 2013Article
- Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src.Acta pharmacologica Sinica · 2011Article
- Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.RNA (New York, N.Y.) · 2008Article
- Class I PI3K in oncogenic cellular transformation.Oncogene · 2008Review
- Mining expressed sequence tags identifies cancer markers of clinical interest.BMC bioinformatics · 2006Article
- Review
- Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues.BMC genomics · 2006Article
- Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.Molecular and cellular biology · 2006Article
- Translation initiation factor 4E inhibits differentiation of erythroid progenitors.Molecular and cellular biology · 2005Article
- Significance of the Y-box proteins in human cancers.Journal of molecular and genetic medicine : an international journal of biomedical research · 2005Article
- Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.Molecular and cellular biology · 2005Article
- Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age.Oncogene · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.