ArticleBone marrow transplantation2004
Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response.
Article in Bone marrow transplantation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Pooled it
- Trial
- Review Article on Molecular Basis of Zinc and Copper Interactions in Cancer Physiology.Biological trace element research · 2025Review
- Zinc in Human Health and Infectious Diseases.Biomolecules · 2022Review
- Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats.Metabolic brain disease · 2022Article
- The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients.Clinical nutrition open science · 2022Review
- Zinc Modulates the Priming of T Helper 1, T Helper 17, and T Regulatory Cells in Allogeneic and Autologous in vitro Models.Journal of inflammation research · 2022Article
- Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients.Journal of medical microbiology · 2020Observational
- Hypothyroidism-related zinc deficiency leads to suppression of T lymphocyte activity.Endocrine · 2019Article
- The Intracellular Free Zinc Level Is Vital for Treg Function and a Feasible Tool to Discriminate between Treg and Activated Th Cells.International journal of molecular sciences · 2018Article
- Zinc as a Gatekeeper of Immune Function.Nutrients · 2017Review
- Zinc Signals and Immunity.International journal of molecular sciences · 2017Review
- Zinc supplementation induces CD4European journal of nutrition · 2017Article
- Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.European journal of nutrition · 2017Article
- Roles of Zinc Signaling in the Immune System.Journal of immunology research · 2016Review
- Article
- Testisimmune privilege - AssumptionsAnimal reproduction · 2013Article
- Gestational zinc deficiency impairs humoral and cellular immune responses to hepatitis B vaccination in offspring mice.PloS one · 2013Article
- The essential toxin: impact of zinc on human health.International journal of environmental research and public health · 2010Review
- Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells.Journal of leukocyte biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is an essential trace element for the immune system. Previously it was shown that zinc inhibits alloreactivity. In our present in vitro experiments, it is shown that zinc maintains the antigenic potency of the host while blocking the allogeneic response. These results were observed in experiments using tetanus toxoid as a well-established recall antigen and the mixed lymphocyte culture as an in vitro model for allogeneic reaction. To prove the in vivo relevance, an ex vivo experimental setup was established. This involved participants taking zinc orally for 1 week. Here it is shown that in vivo zinc application induced the same effect of blocking the mixed lymphocyte culture without influencing tetanus toxoid stimulation. So far, no clinical application studies have been performed, but the observed selective suppression of allogeneic reaction by zinc is the first step towards a new generation of immunosuppressants.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.