ArticleAIDS (London, England)2004
Decline in HIV infectivity following the introduction of highly active antiretroviral therapy.
Article in AIDS (London, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 6 syntheses or guidelines pooled it, 285 citations in OpenAlex.
- Pooled it
- HIV testing and counselling for migrant populations living in high-income countries: a systematic review.European journal of public health · 2013Pooled it
- Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.The Cochrane database of systematic reviews · 2013Pooled it
- Social marketing interventions to increase HIV/STI testing uptake among men who have sex with men and male-to-female transgender women.The Cochrane database of systematic reviews · 2011Pooled it
- HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention.International journal of epidemiology · 2010Pooled it
- Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies.The Lancet. Infectious diseases · 2009Pooled it
- Effect of Yoga on Antiretroviral Adherence Postincarceration in HIV+ Individuals.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2020Trial
- Design of the HPTN 065 (TLC-Plus) study: A study to evaluate the feasibility of an enhanced test, link-to-care, plus treat approach for HIV prevention in the United States.Clinical trials (London, England) · 2017Trial
- Estimating the cost of increasing retention in care for HIV-infected patients: results of the CDC/HRSA retention in care trial.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Modeling HIV transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapy.AIDS care · 2007Trial
- Voluntary medical male circumcision and educational gradient in relation to HIV infection among sexually active adult men in Eswatini: evidence from the national surveys in 2006-2007 and 2016.International health · 2024Article
- Taking a step back from testing: Preanalytical considerations in molecular infectious disease diagnostics.Clinical biochemistry · 2023Review
- Staged HIV transmission and treatment in a dynamic model with long-term partnerships.Journal of mathematical biology · 2023Article
- Article
- HIV-1 heterosexual transmission and association with sexually transmitted infections in the era of treatment as prevention.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Multiple exposures, reinfection and risk of progression to active tuberculosis.Royal Society open science · 2019Article
- The Cost-Effectiveness of Financial Incentives for Viral Suppression: HPTN 065 Study.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2019Article
- Year 2 of Affordable Care Act Qualified Health Plans (QHPs) in a Medicaid Nonexpansion State: QHPs Associated With Viral Suppression for Virginia AIDS Drug Assistance Program Clients.Open forum infectious diseases · 2018Article
- Sexual Risk Behaviors of Patients with HIV/AIDS over the Course of Antiretroviral Treatment in Northern Vietnam.International journal of environmental research and public health · 2018Article
- High prevalence of HIV-1 transmitted drug resistance among therapy-naïve Burmese entering travelers at Dehong ports in Yunnan, China.BMC infectious diseases · 2018Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveLittle is known about the degree to which widespread use of antiretroviral therapy in a community reduces uninfected individuals' risk of acquiring HIV. We estimated the degree to which the probability of HIV infection from an infected partner (the infectivity) declined following the introduction of highly active antiretroviral therapy (HAART) in San Francisco.
designHomosexual men from the San Francisco Young Men's Health Study, who were initially uninfected with HIV, were asked about sexual practices, and tested for HIV antibodies at each of four follow-up visits during a 6-year period spanning the advent of widespread use of HAART (1994-1999).
methodsWe estimated the infectivity of HIV (per-partnership probability of transmission from an infected partner) using a probabilistic risk model based on observed incident infections and self-reported sexual risk behavior, and tested the hypothesis that infectivity was the same before and after HAART was introduced.
resultsA total of 534 homosexual men were evaluated. Decreasing trends in HIV seroincidence were observed despite increases in reported number of unprotected receptive anal intercourse partners. Conservatively assuming a constant prevalence of HIV infection between 1994 and 1999, HIV infectivity decreased from 0.120 prior to widespread use of HAART, to 0.048 after the widespread use of HAART- a decline of 60% (P=0.028).
conclusionsUse of HAART by infected persons in a community appears to reduce their infectiousness and therefore may provide an important HIV prevention tool.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.