ArticleProceedings of the National Academy of Sciences of the United States of America2004
Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 127 citations in OpenAlex.
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- Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.Scientific reports · 2021Article
- Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion.Developmental cell · 2021Article
- Actin and Myosin in Non-Neuronal Exocytosis.Cells · 2020Review
- Toward a unified picture of the exocytotic fusion pore.FEBS letters · 2018Review
- HCO3- Transport through Anoctamin/Transmembrane Protein ANO1/TMEM16A in Pancreatic Acinar Cells Regulates Luminal pH.The Journal of biological chemistry · 2016Article
- Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells.Endocrinology · 2016Article
- The neuronal porosome complex in health and disease.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- 'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion.Journal of cellular and molecular medicine · 2015Review
- Insulin secretion from beta cells within intact islets: location matters.Clinical and experimental pharmacology & physiology · 2015Review
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- NeuronalJournal of molecular structure · 2014Article
- Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.The Journal of cell biology · 2013Article
- Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell.Diabetologia · 2013Article
- Regulated exocytosis: novel insights from intravital microscopy.Traffic (Copenhagen, Denmark) · 2012Review
- Molecular control of compound Exocytosis: A key role for VAMP8.Communicative & integrative biology · 2012Article
- Linking differences in membrane tension with the requirement for a contractile actomyosin scaffold during exocytosis in salivary glands.Communicative & integrative biology · 2012Article
- Real-time measurement of F-actin remodelling during exocytosis using Lifeact-EGFP transgenic animals.PloS one · 2012Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The dynamics of the fusion pore that forms between a secretory vesicle and the plasma membrane are important in the regulation of both exocytosis and endocytosis. Here, we describe characteristics of fusion during zymogen granule exocytosis in exocrine pancreatic acinar cells. By using fluorescence recovery after photobleaching techniques, we show that the fusion pore remains open to allow free aqueous exchange with the vesicle lumen. There is no lipid interchange between the plasma and granule membranes during this time, and at the end of its life, the intact granule shrinks in situ, probably by a gradual pinching off of membrane patches. We propose that the protracted fusion pore lifetime is adapted to permit compound exocytosis, whereby the lingering primary granule acts as a conduit through which the contents of a secondary granule can be released. The lack of lipid intermixing may then facilitate selective recycling of granule membrane and preservation of apical membrane integrity.
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