ReviewJournal of cellular and molecular medicine
Anti-atherosclerotic effects of vitamin E--myth or reality?
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 147 citations in OpenAlex.
- Association between nutrient intake and peripheral artery disease: results from the InCHIANTI study.Atherosclerosis · 2006Trial
- Article
- Nutritional Quality and Oxidative Stability during Thermal Processing of Cold-Pressed Oil Blends with 5:1 Ratio of ω6/ω3 Fatty Acids.Foods (Basel, Switzerland) · 2022Article
- Oxidized LDLs as Signaling Molecules.Antioxidants (Basel, Switzerland) · 2021Review
- Dietary micronutrients intake and plasma fibrinogen levels in the general adult population.Scientific reports · 2021Article
- Article
- Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?Antioxidants (Basel, Switzerland) · 2018Review
- Dietary Ingestion of Calories and Micronutrients Modulates the DNA Methylation Profile of Leukocytes from Older Individuals.The journal of nutrition, health & aging · 2018Article
- Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation.Acta biomaterialia · 2017Article
- Alpha-tocopherol ameliorates experimental autoimmune encephalomyelitis through the regulation of Th1 cells.Iranian journal of basic medical sciences · 2016Article
- OTC Antioxidant Products for the Treatment of Cardiovascular and other Disorders: Popular Myth or Fact?Journal of pharmacovigilance · 2015Article
- Gene expression profile of high-fat diet-fed C57BL/6J mice: in search of potential role of azelaic acid.Journal of physiology and biochemistry · 2015Article
- Antioxidative and antiatherogenic effects of flaxseed, α-tocopherol and their combination in diabetic hamsters fed with a high-fat diet.Experimental and therapeutic medicine · 2015Article
- Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection.Journal of lipid research · 2013Review
- Isoforms of Vitamin E Differentially Regulate PKCJournal of clinical & cellular immunology · 2013Article
- Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage.Disease markers · 2013Review
- Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants.Antioxidants & redox signaling · 2011Review
- Isoforms of vitamin E differentially regulate inflammation.Endocrine, metabolic & immune disorders drug targets · 2010Review
- Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women.The American journal of clinical nutrition · 2010Article
- Antioxidant vitamins and their use in preventing cardiovascular disease.Molecules (Basel, Switzerland) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis and its complications such as coronary heart disease, myocardial infarction and stroke are the leading causes of death in the developed world. High blood pressure, diabetes, smoking and a diet high in cholesterol and lipids clearly increase the likelihood of premature atherosclerosis, albeit other factors, such as the individual genetic makeup, may play an additional role. Several epidemiological studies and intervention trials have been performed with vitamin E, and some of them showed that it prevents atherosclerosis. For a long time, vitamin E was assumed to act by decreasing the oxidation of LDL, a key step in atherosclerosis initiation. However, at the cellular level, vitamin E acts by inhibition of smooth muscle cell proliferation, platelet aggregation, monocyte adhesion, oxLDL uptake and cytokine production, all reactions implied in the progression of atherosclerosis. Recent research revealed that these effects are not the result of the antioxidant activity of vitamin E, but rather of precise molecular actions of this compound. It is assumed that specific interactions of vitamin E with enzymes and proteins are at the basis of its non-antioxidant effects. Vitamin E influences the activity of several enzymes (e.g. PKC, PP2A, COX-2, 5-lipooxygenase, nitric oxide synthase, NADPH-oxidase, superoxide dismutase, phopholipase A2) and modulates the expression of genes that are involved in atherosclerosis (e.g. scavenger receptors, integrins, selectins, cytokines, cyclins). These interactions promise to reveal the biological properties of vitamin E and allow designing better strategies for the protection against atherosclerosis progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.