ArticleBMC genomics2004
Transcriptional signature of an adult brain tumor in Drosophila.
Article in BMC genomics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The RNA-binding activity of theRNA biology · 2026Article
- RNA-binding is the essential biological function of thebioRxiv : the preprint server for biology · 2026Article
- The TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex.Nucleic acids research · 2024Article
- Generation of Mutants from the 57B Region ofGenes · 2023Article
- Molecular and biological functions of TRIM-NHL RNA-binding proteins.Wiley interdisciplinary reviews. RNA · 2021Review
- Drosophila as a Model for Tumor-Induced Organ Wasting.Advances in experimental medicine and biology · 2019Review
- A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in AdultG3 (Bethesda, Md.) · 2018Article
- The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.eLife · 2018Article
- Integrated Proteomic and Genomic Analysis of Gastric Cancer Patient Tissues.Journal of proteome research · 2015Article
- Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation.Genome biology · 2013Article
- Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation.Stem cells international · 2012Article
- Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.Cell stem cell · 2011Article
- Loss of heterozygosity of TRIM3 in malignant gliomas.BMC cancer · 2009Article
- Drosophila asymmetric division, polarity and cancer.Oncogene · 2008Review
- The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.PloS one · 2008Article
- Blurring borders: innate immunity with adaptive features.Clinical & developmental immunology · 2007Review
- The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis.Genome biology · 2005Article
- Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMutations and gene expression alterations in brain tumors have been extensively investigated, however the causes of brain tumorigenesis are largely unknown. Animal models are necessary to correlate altered transcriptional activity and tumor phenotype and to better understand how these alterations cause malignant growth. In order to gain insights into the in vivo transcriptional activity associated with a brain tumor, we carried out genome-wide microarray expression analyses of an adult brain tumor in Drosophila caused by homozygous mutation in the tumor suppressor gene brain tumor (brat).
resultsTwo independent genome-wide gene expression studies using two different oligonucleotide microarray platforms were used to compare the transcriptome of adult wildtype flies with mutants displaying the adult bratk06028 mutant brain tumor. Cross-validation and stringent statistical criteria identified a core transcriptional signature of brat(k06028) neoplastic tissue. We find significant expression level changes for 321 annotated genes associated with the adult neoplastic brat(k06028) tissue indicating elevated and aberrant metabolic and cell cycle activity, upregulation of the basal transcriptional machinery, as well as elevated and aberrant activity of ribosome synthesis and translation control. One fifth of these genes show homology to known mammalian genes involved in cancer formation.
conclusionOur results identify for the first time the genome-wide transcriptional alterations associated with an adult brain tumor in Drosophila and reveal insights into the possible mechanisms of tumor formation caused by homozygous mutation of the translational repressor brat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.