Trial reportBritish journal of clinical pharmacology2004
Effect of duloxetine on tolterodine pharmacokinetics in healthy volunteers.
Trial report in British journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Pharmacokinetics and tolerability of duloxetine following oral administration to healthy Chinese subjects.Clinical pharmacokinetics · 2007Trial
- Physiologically-Based Pharmacokinetic Modeling for the Prediction of CYP2D6-Mediated Gene-Drug-Drug Interactions.CPT: pharmacometrics & systems pharmacology · 2019Article
- Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Review
- Duloxetine: clinical pharmacokinetics and drug interactions.Clinical pharmacokinetics · 2011Review
- Duloxetine for treatment of male sphincteric incontinence following partial conus medullaris infarction after coronary bypass surgery.Cases journal · 2009Article
- Urinary Side Effects of Duloxetine in the Treatment of Depression and Stress Urinary Incontinence.Primary care companion to the Journal of clinical psychiatry · 2004Article
- Duloxetine Treatment of Stress Urinary Incontinence in Women Does Not Induce Mania or Hypomania.Primary care companion to the Journal of clinical psychiatry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of duloxetine on the pharmacokinetics and tolerability of tolterodine and its active 5-hydroxymethyl metabolite (5-HM).
methodsSixteen healthy subjects received two 5-day treatment regimens in a randomized, double-blinded, crossover fashion: tolterodine (2 mg, BID) + duloxetine (40 mg, BID), tolterodine (2 mg, BID) + duloxetine placebo (BID). Plasma concentrations of tolterodine and 5-HM were measured on day 5. Adverse events, clinical safety laboratory data and vital signs were assessed during the study.
resultsDuloxetine increased the AUC(tau,ss) of tolterodine by 71%[geometric mean, 95% confidence interval (CI) 31, 123], and its C(max,ss) by 64% (CI 30, 106), and prolonged its t(1/2) by 14% (CI 1, 28). Duloxetine did not affect the plasma concentrations or t(1/2) of 5-HM. Laboratory data and vital signs did not reveal any clinically significant changes or abnormalities.
conclusionsDuloxetine exhibited minor inhibitory effects on the pharmacokinetics of tolterodine but not 5-HM. Coadministration of these drugs was well tolerated and demonstrated no significant safety findings in the studied population. These findings suggest that there should not be a need for routine adjustment of tolterodine dosage in the presence of duloxetine.
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