ArticleThe Biochemical journal2004
Segregation of two glutaminase isoforms in islets of Langerhans.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Minocycline AmelioratesBrain sciences · 2025Article
- Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia.Scientific reports · 2023Article
- Prognostic and Immunological Significance of the Molecular Subtypes and Risk Signatures Based on Cuproptosis in Hepatocellular Carcinoma.Mediators of inflammation · 2023Article
- Glutamate is an essential mediator in glutamine-amplified insulin secretion.Journal of diabetes investigation · 2021Article
- Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate.Journal of neuroinflammation · 2018Article
- Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice.Brain, behavior, and immunity · 2017Article
- Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice.The Journal of biological chemistry · 2014Article
- Role of diabetes mellitus on hepatic encephalopathy.Metabolic brain disease · 2013Review
- IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.Journal of neurochemistry · 2013Article
- Article
- Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage.Journal of neurochemistry · 2009Article
- Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.Clinical neuroscience research · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in beta-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in alpha-cells, LGA was very abundant in beta-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.