ArticleAmerican journal of human genetics2004
A high-density admixture map for disease gene discovery in african americans.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 278 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Architecture of Plasma T-PA and PAI-1
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
Who cites it
278 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluating reported candidate gene associations with polycystic ovary syndrome.Fertility and sterility · 2013Pooled it
- Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.Human molecular genetics · 2011Pooled it
- Equal Treatment, Unequal Outcomes? Debunking the Racial Disparity in Renin Angiotensin Aldosterone System Inhibitor-Associated Reduction in Heart Failure Hospitalizations.Journal of cardiac failure · 2025Trial
- A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.Human molecular genetics · 2018Trial
- Follow-up to genome-wide linkage and admixture mapping studies implicates components of the extracellular matrix in susceptibility to and size of uterine fibroids.Fertility and sterility · 2015Trial
- Trial
- Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.Diabetes · 2010 · on this mapTrial
- A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.American journal of human genetics · 2026Article
- Article
- Admixture Mapping of Lipid Traits in Hispanic Americans.Journal of the American Heart Association · 2025Article
- Differential results of genetic risk scoring for multiple sclerosis in European and African American populations.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Combined Effects of Metals, PCBs, Dioxins, and Furans on Cardiovascular Dysfunction.Journal of xenobiotics · 2025Article
- Insights from the Biorepository and Integrative Genomics pediatric resource.Nature communications · 2025Article
- The Biorepository and Integrative Genomics resource for inclusive genomics: insights from a diverse pediatric and admixed cohort.medRxiv : the preprint server for health sciences · 2025Article
- Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Overview of short and long-term management of cardiovascular disease in the cancer patient: Research-driven guidance for the clinician.American heart journal plus : cardiology research and practice · 2023Article
- Universal genome-wide association studies: Powerful joint ancestry and association testing.HGG advances · 2023Article
- Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023Review
- Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Simultaneous inference of parental admixture proportions and admixture times from unphased local ancestry calls.American journal of human genetics · 2022Article
218 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Funding
Abstract
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing approximately 450000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3011 as a MALD map (1.2 cM average spacing). We estimate that this map is approximately 70% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.