ArticleProceedings of the National Academy of Sciences of the United States of America2004
Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 113 citations in OpenAlex.
- Novel dopamine 4 receptor ligands differentially ameliorate ADHD-like behaviors in spontaneously hypertensive rats.Psychopharmacology · 2026Article
- The Pivotal Distinction between Antagonists' and Agonists' Binding into Dopamine D4 Receptor-MD and FMO/PIEDA Studies.International journal of molecular sciences · 2024Article
- Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies.Brain sciences · 2023Review
- Dopamine, Erectile Function and Male Sexual Behavior from the Past to the Present: A Review.Brain sciences · 2022Review
- Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870.eLife · 2019Article
- Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.Scientific reports · 2019Article
- Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets.Psychopharmacology · 2015Article
- Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.ACS medicinal chemistry letters · 2013Article
- Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptor.The Journal of pharmacology and experimental therapeutics · 2012Article
- Self-administration of agonists selective for dopamine D2, D3, and D4 receptors by rhesus monkeys.Behavioural pharmacology · 2012Article
- Effects of selective dopaminergic compounds on a delay-discounting task.Behavioural pharmacology · 2011Article
- Future prospects in the treatment of erectile dysfunction: focus on avanafil.Drug design, development and therapy · 2011Review
- Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors.Journal of medicinal chemistry · 2010Article
- The future is today: emerging drugs for the treatment of erectile dysfunction.Expert opinion on emerging drugs · 2010Review
- The dopamine D4 receptor: biochemical and signalling properties.Cellular and molecular life sciences : CMLS · 2010Review
- Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.The Journal of pharmacology and experimental therapeutics · 2009Article
- Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.Psychopharmacology · 2009Article
- Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.Bioorganic & medicinal chemistry · 2009Article
- Hormesis and medicine.British journal of clinical pharmacology · 2008Review
- Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here we report that the dopamine D(4) receptor plays a role in the regulation of penile function. ABT-724 is a selective dopamine D(4) receptor agonist that activates human dopamine D(4) receptors with an EC(50) of 12.4 nM and 61% efficacy, with no effect on dopamine D(1), D(2), D(3), or D(5) receptors. ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an effect that is blocked by haloperidol and clozapine but not by domperidone. A proerectile effect is observed after intracerebroventricular but not intrathecal administration, suggesting a supraspinal site of action. s.c. injections of ABT-724 increase intracavernosal pressure in awake freely moving rats. In the presence of sildenafil, a potentiation of the proerectile effect of ABT-724 is observed in conscious rats. The ability of ABT-724 to facilitate penile erection together with the favorable side-effect profile indicates that ABT-724 could be useful for the treatment of erectile dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.