ArticleNucleic acids research1992
Splicing signals in Drosophila: intron size, information content, and consensus sequences.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
175 citing papers in PubMed, 380 citations in OpenAlex.
- The stability of m6A-marked transcripts is linked to cell identity in planarians.Nucleic acids research · 2026Article
- Purifying selection against spurious splicing signals contributes to the base composition evolution of the polypyrimidine tract.Journal of evolutionary biology · 2023Article
- The evolutionary dynamics that retain long neutral genomic sequences in face of indel deletion bias: a model and its application to human introns.Open biology · 2022Article
- Intron size minimisation in teleosts.BMC genomics · 2022Article
- An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report.American journal of medical genetics. Part A · 2022Article
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- Evidence for a force favoring GC over AT at short intronic sites in Drosophila simulans and Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene.Scientific reports · 2020Article
- In silico identification and assessment of insecticide target sites in the genome of the small hive beetle, Aethina tumida.BMC genomics · 2020Article
- Modeling one thousand intron length distributions with fitild.Bioinformatics (Oxford, England) · 2018Article
- The kinetics of pre-mRNA splicing in theeLife · 2017Article
- Genotyping and Bio-Sensing Chemosensory Proteins in Insects.Sensors (Basel, Switzerland) · 2017Review
- mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Identification of minimal eukaryotic introns through GeneBase, a user-friendly tool for parsing the NCBI Gene databank.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci.RNA (New York, N.Y.) · 2015Article
- Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.Disease models & mechanisms · 2014Article
- The Chironomus tentans genome sequence and the organization of the Balbiani ring genes.BMC genomics · 2014Article
- Evolution of splicing regulatory networks in Drosophila.Genome research · 2014Article
- Parallel histories of horizontal gene transfer facilitated extreme reduction of endosymbiont genomes in sap-feeding insects.Molecular biology and evolution · 2014Article
- Article
115 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
A database of 209 Drosophila introns was extracted from Genbank (release number 64.0) and examined by a number of methods in order to characterize features that might serve as signals for messenger RNA splicing. A tight distribution of sizes was observed: while the smallest introns in the database are 51 nucleotides, more than half are less than 80 nucleotides in length, and most of these have lengths in the range of 59-67 nucleotides. Drosophila splice sites found in large and small introns differ in only minor ways from each other and from those found in vertebrate introns. However, larger introns have greater pyrimidine-richness in the region between 11 and 21 nucleotides upstream of 3' splice sites. The Drosophila branchpoint consensus matrix resembles C T A A T (in which branch formation occurs at the underlined A), and differs from the corresponding mammalian signal in the absence of G at the position immediately preceding the branchpoint. The distribution of occurrences of this sequence suggests a minimum distance between 5' splice sites and branchpoints of about 38 nucleotides, and a minimum distance between 3' splice sites and branchpoints of 15 nucleotides. The methods we have used detect no information in exon sequences other than in the few nucleotides immediately adjacent to the splice sites. However, Drosophila resembles many other species in that there is a discontinuity in A + T content between exons and introns, which are A + T rich.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.